{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Liu C"],"funding":["Shanghai Hospital Development Center","Capacity building for multidisciplinary cooperation in diagnosis and treatment of major metabolic diseases","Noncommunicable Chronic Diseases-National Science and Technology Major Project","the Shanghai Medical and Health Development Foundation","the National Natural Science Foundation of China","The Leader Project of the Oriental Talent Program in 2022"],"pagination":["225"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12103019"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["24(1)"],"pubmed_abstract":["<h4>Background</h4>Elevated blood pressure (BP) is a key contributor to the progression of arterial stiffness and the incidence of diabetic kidney disease (DKD). Cumulative BP load enables the evaluation of long-term BP exposure, but the BP targets used to calculate it vary across studies. This study aimed to compare the predictive performance of cumulative BP load calculated using different clinically recommended BP targets.<h4>Methods</h4>This multicenter longitudinal study included participants with type 2 diabetes from 10 diabetes centers. Cumulative BP load was calculated using various clinically recommended BP targets (SBP < 140 mmHg, < 130 mmHg, and < 120 mmHg). The primary outcomes were the progression of arterial stiffness, assessed by brachial-ankle pulse wave velocity (ba-PWV) c"],"journal":["Cardiovascular diabetology"],"pubmed_title":["Cumulative blood pressure load as a predictor of arterial stiffness progression and incident diabetic kidney disease: a multicenter longitudinal study."],"pmcid":["PMC12103019"],"funding_grant_id":["SHDC22022301","No. 82270896","No.2023ZD0508100","No. Z155080000004","No.153","No. DMRFP_II_01"],"pubmed_authors":["Peng Y","Ji B","Liang Y","Xu F","Zheng Q","Dong Q","Ke T","Li L","Dai Y","Zhang Y","Wang W","Liu C","Zhao D","Shi J","Wang Y"],"additional_accession":[]},"is_claimable":false,"name":"Cumulative blood pressure load as a predictor of arterial stiffness progression and incident diabetic kidney disease: a multicenter longitudinal study.","description":"<h4>Background</h4>Elevated blood pressure (BP) is a key contributor to the progression of arterial stiffness and the incidence of diabetic kidney disease (DKD). Cumulative BP load enables the evaluation of long-term BP exposure, but the BP targets used to calculate it vary across studies. This study aimed to compare the predictive performance of cumulative BP load calculated using different clinically recommended BP targets.<h4>Methods</h4>This multicenter longitudinal study included participants with type 2 diabetes from 10 diabetes centers. Cumulative BP load was calculated using various clinically recommended BP targets (SBP < 140 mmHg, < 130 mmHg, and < 120 mmHg). The primary outcomes were the progression of arterial stiffness, assessed by brachial-ankle pulse wave velocity (ba-PWV) c","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 May","modification":"2026-06-02T00:31:03.022Z","creation":"2026-05-24T03:07:11.982Z"},"accession":"S-EPMC12103019","cross_references":{"pubmed":["40413512"],"doi":["10.1186/s12933-025-02785-7"]}}