{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Qin F"],"funding":["Natural Science Foundation of Chongqing (Natural Science Foundation of Chongqing Municipality)","National Natural Science Foundation of China (National Science Foundation of China)"],"pagination":["4828"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12103590"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(1)"],"pubmed_abstract":["Ovarian cancer has the highest mortality rate among gynecologic tumors worldwide, with unclear underlying mechanisms of pathogenesis. RNA-binding proteins (RBPs) primarily direct post-transcriptional regulation through modulating RNA metabolism. Recent evidence demonstrates that RBPs are also implicated in transcriptional control. However, the role and mechanism of RBP-mediated transcriptional regulation in tumorigenesis remain largely unexplored. Here, we show that the RBP heterogeneous ribonucleoprotein L (hnRNPL) interacts with chromatin and regulates gene transcription by forming phase-separated condensates in ovarian cancer. hnRNPL phase separation activates PIK3CB transcription and glycolysis, thus promoting ovarian cancer progression. Notably, we observe that the PIK3CB promoter is "],"journal":["Nature communications"],"pubmed_title":["hnRNPL phase separation activates PIK3CB transcription and promotes glycolysis in ovarian cancer."],"pmcid":["PMC12103590"],"funding_grant_id":["32101164","82273156","82072886","CSTB2023NSCQ-MSX0338","CSTB2022NSCQ-MSX0897"],"pubmed_authors":["Cheng C","Ren Y","Zuo X","Luo F","Yi P","Wang H","Yang D","Liu T","Yang C","Xu J","Liu X","Luo Q","Yang Y","Wei Q","Qin F","Wang W","Luo X","Wang Y","Tang Y"],"additional_accession":[]},"is_claimable":false,"name":"hnRNPL phase separation activates PIK3CB transcription and promotes glycolysis in ovarian cancer.","description":"Ovarian cancer has the highest mortality rate among gynecologic tumors worldwide, with unclear underlying mechanisms of pathogenesis. RNA-binding proteins (RBPs) primarily direct post-transcriptional regulation through modulating RNA metabolism. Recent evidence demonstrates that RBPs are also implicated in transcriptional control. However, the role and mechanism of RBP-mediated transcriptional regulation in tumorigenesis remain largely unexplored. Here, we show that the RBP heterogeneous ribonucleoprotein L (hnRNPL) interacts with chromatin and regulates gene transcription by forming phase-separated condensates in ovarian cancer. hnRNPL phase separation activates PIK3CB transcription and glycolysis, thus promoting ovarian cancer progression. Notably, we observe that the PIK3CB promoter is ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 May","modification":"2026-06-02T02:42:19.736Z","creation":"2026-04-13T03:12:25.485Z"},"accession":"S-EPMC12103590","cross_references":{"pubmed":["40413189"],"doi":["10.1038/s41467-025-60115-7"]}}