biostudies-literatureUnknown27(1)Nowrouzi-Kia B<h4>Background</h4>Systemic lupus erythematosus (SLE) disease symptoms that can significantly restrict work ability and work participation resulting in reduced mental well-being. This study investigates the significant impact of work participation and disability on the mental wellbeing, health-related quality of life, and disease-related outcomes in individuals with SLE.<h4>Methods</h4>With the objective of creating an SLE-related functional profile rooted in work disability (WD) prevention, 46 SLE patients were purposively recruited from Canadian medical centres. Through semi-structured interviews guided by a WD prevention framework, factors associated with WD and lived experiences of SLE-related WD were qualitatively explored. Braun and Clarke's six-stage inductive thematic analysis was Arthritis research & therapy114https://www.ebi.ac.uk/biostudies/studies/S-EPMC12105366biostudies-literatureFunctional work disability from the perspectives of persons with systemic lupus erythematosus: a qualitative thematic analysis.PMC12105366Urowitz MBSaade-Cleves NAvina-Zubieta ANielsen WNowrouzi-Kia BSanchez-Guerrero JTouma ZSadek MReynolds JHaaland DHowe ASBonilla DFortin PRLi ABani-Fatemi APeschken CKatz PKavkan MTan JLim LSHGladman DDPope JShaw WKeeling SJules KBingham KSIvory CFox MTfalseFunctional work disability from the perspectives of persons with systemic lupus erythematosus: a qualitative thematic analysis.<h4>Background</h4>Systemic lupus erythematosus (SLE) disease symptoms that can significantly restrict work ability and work participation resulting in reduced mental well-being. This study investigates the significant impact of work participation and disability on the mental wellbeing, health-related quality of life, and disease-related outcomes in individuals with SLE.<h4>Methods</h4>With the objective of creating an SLE-related functional profile rooted in work disability (WD) prevention, 46 SLE patients were purposively recruited from Canadian medical centres. Through semi-structured interviews guided by a WD prevention framework, factors associated with WD and lived experiences of SLE-related WD were qualitatively explored. Braun and Clarke's six-stage inductive thematic analysis was 2025-01-01T00:00:00Z2025 May2025-07-26T03:07:02.664Z2025-07-26T03:07:02.664ZS-EPMC121053664042022910.1186/s13075-025-03572-1