{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15"],"submitter":["von Ameln Lovison O"],"pubmed_abstract":["It is argued that commensal bacteria in the upper respiratory tract (URT) protect against pathogen colonization and infection, including respiratory viruses. Given that the microbiome can mediate immune modulation, a link between the URT microbiome (URTM) and COVID-19 susceptibility and severity is expected. This 16S metagenomics cross-sectional study assessed URTM composition, metabolic prediction, and association with laboratory biomarkers in non-COVID-19 pneumonia (NO-CoV), moderate (M-CoV), severe (S-CoV) COVID-19 patients, as well as COVID-19-negative, asymptomatic (NC) patients. The S-CoV group exhibited reduced URTM diversity, primarily due to a decreased abundance of eubiotic taxa. Some of these taxa (e.g., <i>Haemophilus</i> sp., <i>Neisseria</i> sp.) were also associated with inf"],"journal":["Frontiers in cellular and infection microbiology"],"pagination":["1531084"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12106449"],"repository":["biostudies-literature"],"pubmed_title":["Unveiling the role of the upper respiratory tract microbiome in susceptibility and severity to COVID-19."],"pmcid":["PMC12106449"],"pubmed_authors":["Weber LG","Barth AL","Martins AF","Simon Coitinho A","von Ameln Lovison O","Zempulski Volpato FC"],"additional_accession":[]},"is_claimable":false,"name":"Unveiling the role of the upper respiratory tract microbiome in susceptibility and severity to COVID-19.","description":"It is argued that commensal bacteria in the upper respiratory tract (URT) protect against pathogen colonization and infection, including respiratory viruses. Given that the microbiome can mediate immune modulation, a link between the URT microbiome (URTM) and COVID-19 susceptibility and severity is expected. This 16S metagenomics cross-sectional study assessed URTM composition, metabolic prediction, and association with laboratory biomarkers in non-COVID-19 pneumonia (NO-CoV), moderate (M-CoV), severe (S-CoV) COVID-19 patients, as well as COVID-19-negative, asymptomatic (NC) patients. The S-CoV group exhibited reduced URTM diversity, primarily due to a decreased abundance of eubiotic taxa. Some of these taxa (e.g., <i>Haemophilus</i> sp., <i>Neisseria</i> sp.) were also associated with inf","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025","modification":"2026-05-29T17:04:09.725Z","creation":"2026-04-08T05:28:09.445Z"},"accession":"S-EPMC12106449","cross_references":{"pubmed":["40433668"],"doi":["10.3389/fcimb.2025.1531084"]}}