{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Rosa-Baez C"],"funding":["Spanish Ministry of University","Redes de Investigación Cooperativa Orientadas a Resultados en Salud","MCIN/AEI/10.13039/501100011033","Miguel Servet","Instituto de Salud Carlos III","FPU","Spanish Ministry of Science Innovation and Universities"],"pagination":["4022-4031"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12107044"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["64(6)"],"pubmed_abstract":["<h4>Objectives</h4>Coronavirus disease 2019 (COVID-19) and SSc share multiple similarities in their clinical manifestations, alterations in immune response and therapeutic options. These resemblances have also been identified in other immune-mediated inflammatory diseases where a common genetic component has been found. Thus, we decided to evaluate for the first time this shared genetic architecture with SSc.<h4>Methods</h4>For this study, we retrieved genomic data from two European-ancestry cohorts: 2 597 856 individuals from The COVID-19 Host Genetics Initiative consortium, and 26 679 individuals from the largest genomic scan in SSc. We performed a cross-trait meta-analyses including >9.3 million single nucleotide polymorphisms. Finally, we conducted functional annotation to prioritize p"],"journal":["Rheumatology (Oxford, England)"],"pubmed_title":["Cross-trait GWAS in COVID-19 and systemic sclerosis reveals novel genes implicated in fibrotic and inflammation pathways."],"pmcid":["PMC12107044"],"funding_grant_id":["RD21/0002/0039","FPU21/02746","MICIU/AEI/10.13039/501100011033","FPU22/01652","CP21/00132","PREP2022-000712","RYC2022-036635-I"],"pubmed_authors":["Rosa-Baez C","Rodriguez-Martin I","Martin J","Acosta-Herrera M","Borrego-Yaniz G","Kerick M","Ortiz-Fernandez L"],"additional_accession":[]},"is_claimable":false,"name":"Cross-trait GWAS in COVID-19 and systemic sclerosis reveals novel genes implicated in fibrotic and inflammation pathways.","description":"<h4>Objectives</h4>Coronavirus disease 2019 (COVID-19) and SSc share multiple similarities in their clinical manifestations, alterations in immune response and therapeutic options. These resemblances have also been identified in other immune-mediated inflammatory diseases where a common genetic component has been found. Thus, we decided to evaluate for the first time this shared genetic architecture with SSc.<h4>Methods</h4>For this study, we retrieved genomic data from two European-ancestry cohorts: 2 597 856 individuals from The COVID-19 Host Genetics Initiative consortium, and 26 679 individuals from the largest genomic scan in SSc. We performed a cross-trait meta-analyses including >9.3 million single nucleotide polymorphisms. Finally, we conducted functional annotation to prioritize p","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jun","modification":"2026-04-26T03:14:27.455Z","creation":"2026-04-26T03:08:57.636Z"},"accession":"S-EPMC12107044","cross_references":{"pubmed":["39878951"],"doi":["10.1093/rheumatology/keaf028"]}}