biostudies-literatureRuiz-Irastorza GHezkuntza, Hizkuntza Politika Eta Kultura Saila, Eusko Jaurlaritzae001562https://www.ebi.ac.uk/biostudies/studies/S-EPMC12107586biostudies-literatureUnknown12(1)<h4>Objective</h4>To assess the efficacy and toxicity of the Lupus-Cruces Nephritis (LCN) protocol compared with standard of care (SOC) with cyclophosphamide (CYC) or mycophenolate in patients with lupus nephritis (LN) during an extended follow-up time up to 10 years.<h4>Methods</h4>Patients with biopsy-proven class III, IV or V LN treated with LCN were compared with SOC. Patients in the LCN were treated with a CYC plus repeated methylprednisolone pulse-based regimen. The achievement of complete renal response (CRR) and the progression to chronic kidney disease (CKD) were the two main outcomes. Glucocorticoid (GC)-related toxicity, major infections and damage accrual were also analysed. A propensity score (PS)-adjusted multivariate analysis was used to overcome the confounding-by-indicatioLupus science & medicineLong-term efficacy and safety of the Lupus-Cruces Nephritis protocol: a propensity score study of the Lupus-Cruces and Lupus-Bordeaux cohorts.PMC12107586IT 1512-22Ruiz-Irastorza GParedes Ruiz DOsorio AMarin-Garcia BDuena-Bartolome LLazaro EfalseLong-term efficacy and safety of the Lupus-Cruces Nephritis protocol: a propensity score study of the Lupus-Cruces and Lupus-Bordeaux cohorts.<h4>Objective</h4>To assess the efficacy and toxicity of the Lupus-Cruces Nephritis (LCN) protocol compared with standard of care (SOC) with cyclophosphamide (CYC) or mycophenolate in patients with lupus nephritis (LN) during an extended follow-up time up to 10 years.<h4>Methods</h4>Patients with biopsy-proven class III, IV or V LN treated with LCN were compared with SOC. Patients in the LCN were treated with a CYC plus repeated methylprednisolone pulse-based regimen. The achievement of complete renal response (CRR) and the progression to chronic kidney disease (CKD) were the two main outcomes. Glucocorticoid (GC)-related toxicity, major infections and damage accrual were also analysed. A propensity score (PS)-adjusted multivariate analysis was used to overcome the confounding-by-indicatio2025-01-01T00:00:00Z2025 May2025-07-26T03:06:03.771Z2025-07-26T03:06:03.771ZS-EPMC121075864042526310.1136/lupus-2025-001562