{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["20(5)"],"submitter":["Schachtschneider KM"],"funding":["Illinois Health Disparities Initiative Grant, University of Illinois Urbana-Champaign Roy J. Carver Biotechnology Center"],"pubmed_abstract":["Combined hepatocellular carcinoma-cholangiocarcinoma (HCC-CCA) is a rare liver tumor comprising histologic features of both HCC and CCA. Due to its heterogeneous nature, treatment of combined HCC-CCA is a significant clinical challenge and prognosis remains poor. Therefore, further understanding of the tumor biology underlying the individual subtypes of this mixed tumor is required to improve treatment stratification and optimize treatment strategies. This study sought to identify altered epigenetic regulation and gene expression patterns in the individual components of combined HCC-CCA. Formalin fixed paraffin embedded (FFPE) tumor specimens from 9 patients diagnosed with combined HCC-CCA were utilized in this study. Hematoxylin and eosin (H&E) staining was performed for each sample, and "],"journal":["PloS one"],"pagination":["e0324145"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12112136"],"repository":["biostudies-literature"],"pubmed_title":["Epigenetic regulation of individual components of combined hepatocellular-cholangiocarcinoma."],"pmcid":["PMC12112136"],"pubmed_authors":["Schook LB","Redlon LN","Huang YH","Lokken RP","Schachtschneider KM","Gaba RC","Guzman G"],"additional_accession":[]},"is_claimable":false,"name":"Epigenetic regulation of individual components of combined hepatocellular-cholangiocarcinoma.","description":"Combined hepatocellular carcinoma-cholangiocarcinoma (HCC-CCA) is a rare liver tumor comprising histologic features of both HCC and CCA. Due to its heterogeneous nature, treatment of combined HCC-CCA is a significant clinical challenge and prognosis remains poor. Therefore, further understanding of the tumor biology underlying the individual subtypes of this mixed tumor is required to improve treatment stratification and optimize treatment strategies. This study sought to identify altered epigenetic regulation and gene expression patterns in the individual components of combined HCC-CCA. Formalin fixed paraffin embedded (FFPE) tumor specimens from 9 patients diagnosed with combined HCC-CCA were utilized in this study. Hematoxylin and eosin (H&E) staining was performed for each sample, and ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025","modification":"2026-05-23T03:15:23.759Z","creation":"2026-05-23T03:07:25.604Z"},"accession":"S-EPMC12112136","cross_references":{"pubmed":["40424447"],"doi":["10.1371/journal.pone.0324145"]}}