{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Santaeufemia S"],"funding":["Genomics Core Facility at the Centre of New Technologies, University of Warsaw","National Science Centre, Poland","Polish Ministry of Science and Higher Education","National Science Center"],"pagination":["4813"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12112623"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["26(10)"],"pubmed_abstract":["The red microalga <i>Cyanidioschyzon merolae</i> inhabits extreme environments with high temperatures (40-56 °C), high acidity (pH 0.05-4), and high concentrations of heavy metals that are lethal to most forms of life. However, information is scarce on the precise adaptation mechanisms of this extremophile to such hostile conditions. Gaining such knowledge is important for understanding the evolution of microorganisms in the early stages of life on Earth characterized by such extreme environments. Through an analysis of the re-programming of the global transcriptome upon the long-term (up to 15 days) exposure of <i>C. merolae</i> to extremely high concentrations of nickel (1 and 3 mM), the key adaptive metabolic pathways and associated molecular components were identified. Our work shows t"],"journal":["International journal of molecular sciences"],"pubmed_title":["Transcriptomics Reveals an Energy-Saving Metabolic Switch in an Extremophilic Red Microalga &lt;i&gt;Cyanidioschyzon merolae&lt;/i&gt; Under Nickel Stress."],"pmcid":["PMC12112623"],"funding_grant_id":["6817/IA/SP/2018","RRID:SCR_022718","2019/33/B/NZ3/01870","2021/05/X/NZ2/01516"],"pubmed_authors":["Kargul J","Marchetto F","Adamska D","Palatini J","Santaeufemia S","Romano P","Goryca K"],"additional_accession":[]},"is_claimable":false,"name":"Transcriptomics Reveals an Energy-Saving Metabolic Switch in an Extremophilic Red Microalga &lt;i&gt;Cyanidioschyzon merolae&lt;/i&gt; Under Nickel Stress.","description":"The red microalga <i>Cyanidioschyzon merolae</i> inhabits extreme environments with high temperatures (40-56 °C), high acidity (pH 0.05-4), and high concentrations of heavy metals that are lethal to most forms of life. However, information is scarce on the precise adaptation mechanisms of this extremophile to such hostile conditions. Gaining such knowledge is important for understanding the evolution of microorganisms in the early stages of life on Earth characterized by such extreme environments. Through an analysis of the re-programming of the global transcriptome upon the long-term (up to 15 days) exposure of <i>C. merolae</i> to extremely high concentrations of nickel (1 and 3 mM), the key adaptive metabolic pathways and associated molecular components were identified. Our work shows t","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 May","modification":"2026-04-26T03:10:21.302Z","creation":"2026-04-26T03:08:40.667Z"},"accession":"S-EPMC12112623","cross_references":{"pubmed":["40429959"],"doi":["10.3390/ijms26104813"]}}