biostudies-literatureUnknown61(5)Akgul MS<i>Background and Objectives:</i> This study compared the effects of blood flow restriction resistance exercise (BFR-RE) and high-load resistance exercise (HL-RE) in voluntary exhaustion on quadriceps muscle adaptations in untrained young males. <i>Materials and Methods:</i> This study used a randomized controlled design that included 30 untrained young males (age = 21.42 ± 2.51). The BFR-RE group performed leg extension exercises with 60% occlusion pressure and 30% of one maximum repetition in volitional exhaustion. The same exercise was conducted at 70% 1RM in the HL-RE group. Fourteen variables were used to evaluate the intervention efficacy, including muscle thickness, stiffness, strength, cross-sectional area (CSA), and subcutaneous fat thickness. Analyses were reported using frequentMedicina (Kaunas, Lithuania)804https://www.ebi.ac.uk/biostudies/studies/S-EPMC12113377biostudies-literatureEffects of Blood Flow Restriction Resistance Exercise Versus Traditional Resistance Exercise in Voluntary Exhaustion on Quadriceps Muscle Adaptations in Untrained Young Males: A Randomized Trial.PMC12113377Akgul MNCiftci ESoslu RCetin TKeskin NKBasdemirci MUysal HSYıldız ZAkgul MSfalseEffects of Blood Flow Restriction Resistance Exercise Versus Traditional Resistance Exercise in Voluntary Exhaustion on Quadriceps Muscle Adaptations in Untrained Young Males: A Randomized Trial.<i>Background and Objectives:</i> This study compared the effects of blood flow restriction resistance exercise (BFR-RE) and high-load resistance exercise (HL-RE) in voluntary exhaustion on quadriceps muscle adaptations in untrained young males. <i>Materials and Methods:</i> This study used a randomized controlled design that included 30 untrained young males (age = 21.42 ± 2.51). The BFR-RE group performed leg extension exercises with 60% occlusion pressure and 30% of one maximum repetition in volitional exhaustion. The same exercise was conducted at 70% 1RM in the HL-RE group. Fourteen variables were used to evaluate the intervention efficacy, including muscle thickness, stiffness, strength, cross-sectional area (CSA), and subcutaneous fat thickness. Analyses were reported using frequent2025-01-01T00:00:00Z2025 Apr2026-05-23T03:12:03.207Z2026-05-23T03:08:12.195ZS-EPMC121133774042876210.3390/medicina61050804