{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Hogan MJ"],"funding":["U.S. Department of Health & Human Services | NIH | Office of Extramural Research, National Institutes of Health","Roy and Diana Vagelos Molecular Life Sciences Program College Alumni Society Research Grant from the University of Pennsylvania","NIAID NIH HHS","In addition to CRI: Aileen K. and Brian L. Roberts Family Foundation via the University of Pennsylvania Institute for Immunology & Immune Health","Cancer Research Institute"],"pagination":["1933-1946"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12116205"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["24(11)"],"pubmed_abstract":["The extent to which unconventional forms of antigen presentation drive T cell immunity is unknown. By convention, CD8 T cells recognize viral peptides, or epitopes, in association with classical major histocompatibility complex (MHC) class I, or MHC-Ia, but immune surveillance can, in some cases, be directed against peptides presented by nonclassical MHC-Ib, in particular the MHC-E proteins (Qa-1 in mice and HLA-E in humans); however, the overall importance of nonclassical responses in antiviral immunity remains unclear. Similarly uncertain is the importance of 'cryptic' viral epitopes, defined as those undetectable by conventional mapping techniques. Here we used an immunopeptidomic approach to search for unconventional epitopes that drive T cell responses in mice infected with influenza "],"journal":["Nature immunology"],"pubmed_title":["Cryptic MHC-E epitope from influenza elicits a potent cytolytic T cell response."],"pmcid":["PMC12116205"],"funding_grant_id":["R21 AI153978","75N93021C00015","R21AI153978","R01 AI046709","R01AI125524","R01 AI125524","R01AI046709","R01AI153064","R01 AI153064","R01AI146101","R01 AI146101"],"pubmed_authors":["Hogan MJ","Lynch KW","Ternette N","Nicastri A","Miller MA","Maheshwari N","Begg BE","Hedgepeth EJ","Eisenlohr LC","Muramatsu H","Pardi N","Brossay L","Reilly SP"],"additional_accession":[]},"is_claimable":false,"name":"Cryptic MHC-E epitope from influenza elicits a potent cytolytic T cell response.","description":"The extent to which unconventional forms of antigen presentation drive T cell immunity is unknown. By convention, CD8 T cells recognize viral peptides, or epitopes, in association with classical major histocompatibility complex (MHC) class I, or MHC-Ia, but immune surveillance can, in some cases, be directed against peptides presented by nonclassical MHC-Ib, in particular the MHC-E proteins (Qa-1 in mice and HLA-E in humans); however, the overall importance of nonclassical responses in antiviral immunity remains unclear. Similarly uncertain is the importance of 'cryptic' viral epitopes, defined as those undetectable by conventional mapping techniques. Here we used an immunopeptidomic approach to search for unconventional epitopes that drive T cell responses in mice infected with influenza ","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Nov","modification":"2026-06-03T06:56:13.082Z","creation":"2026-04-25T03:22:01.101Z"},"accession":"S-EPMC12116205","cross_references":{"pubmed":["37828378"],"doi":["10.1038/s41590-023-01644-5"]}}