{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["11(22)"],"submitter":["Kang J"],"pubmed_abstract":["Cis-regulatory elements (CREs) direct precise gene expression for development and environmental response, yet their spatial organization in crops is largely unknown. We introduce transposase-accessible chromosome conformation capture (TAC-C), a method integrating ATAC-seq and Hi-C to capture fine-scale chromatin interactions in four major crops: rice, sorghum, maize, and wheat. TAC-C reveals a strong association between chromatin interaction frequency and gene expression, particularly emphasizing the conserved roles of chromatin interaction hub anchors and hub genes across crop species. Integrating chromatin structure with population genetics data highlights that chromatin loops connect distal regulatory elements to phenotypic variation. In addition, asymmetrical open chromatin interaction"],"journal":["Science advances"],"pagination":["eadu6565"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12124369"],"repository":["biostudies-literature"],"pubmed_title":["TAC-C uncovers open chromatin interaction in crops and SPL-mediated photosynthesis regulation."],"pmcid":["PMC12124369"],"pubmed_authors":["Lin X","Lin Y","Liu X","Li X","Yang Y","Zhang Z","Xiao J","Zhao P","Xu S","Wang W","Luo X","Liu C","Kang J","Liu F","Song Y"],"additional_accession":[]},"is_claimable":false,"name":"TAC-C uncovers open chromatin interaction in crops and SPL-mediated photosynthesis regulation.","description":"Cis-regulatory elements (CREs) direct precise gene expression for development and environmental response, yet their spatial organization in crops is largely unknown. We introduce transposase-accessible chromosome conformation capture (TAC-C), a method integrating ATAC-seq and Hi-C to capture fine-scale chromatin interactions in four major crops: rice, sorghum, maize, and wheat. TAC-C reveals a strong association between chromatin interaction frequency and gene expression, particularly emphasizing the conserved roles of chromatin interaction hub anchors and hub genes across crop species. Integrating chromatin structure with population genetics data highlights that chromatin loops connect distal regulatory elements to phenotypic variation. In addition, asymmetrical open chromatin interaction","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 May","modification":"2026-06-01T15:36:04.92Z","creation":"2026-04-08T13:36:32.269Z"},"accession":"S-EPMC12124369","cross_references":{"pubmed":["40446043"],"doi":["10.1126/sciadv.adu6565"]}}