biostudies-literatureChatphatthanasiri CChulalongkorn University Faculty of Dentistry100813https://www.ebi.ac.uk/biostudies/studies/S-EPMC12124609biostudies-literatureUnknown75(4)<h4>Introduction and aims</h4>Cockle shells, which are discarded as waste by the food industry, have been used in medical fields. This study aimed to manufacture a newly developed cockle shell-derived bioceramic sealer (NDBS) and evaluate its physical and biological properties.<h4>Methods</h4>Cockle shell-derived tricalcium silicate (C-C₃S) was synthesized via the solid-state reaction technique and analysed for chemical composition and particle size. NDBS was prepared by mixing C-C₃S with specific additives. The chemical composition and surface morphology of fully set sealers were assessed using X-ray diffraction, Fourier-transform infrared spectroscopy, and scanning electron microscopy. Physical properties were tested according to International Organization for StandInternational dental journalFrom Cockle Shell to Bioceramic Root Canal Sealer: The Manufacturing and its Physical and Biological Properties.PMC12124609DRF-67015Chanamuangkon TWasanapiarnpong TChatphatthanasiri CChivatxaranukul PLinsuwanont PfalseFrom Cockle Shell to Bioceramic Root Canal Sealer: The Manufacturing and its Physical and Biological Properties.<h4>Introduction and aims</h4>Cockle shells, which are discarded as waste by the food industry, have been used in medical fields. This study aimed to manufacture a newly developed cockle shell-derived bioceramic sealer (NDBS) and evaluate its physical and biological properties.<h4>Methods</h4>Cockle shell-derived tricalcium silicate (C-C₃S) was synthesized via the solid-state reaction technique and analysed for chemical composition and particle size. NDBS was prepared by mixing C-C₃S with specific additives. The chemical composition and surface morphology of fully set sealers were assessed using X-ray diffraction, Fourier-transform infrared spectroscopy, and scanning electron microscopy. Physical properties were tested according to International Organization for Stand2025-01-01T00:00:00Z2025 Aug2026-03-27T16:24:33.157Z2025-08-30T03:05:36.7ZS-EPMC121246094031829210.1016/j.identj.2025.03.022