biostudies-literatureKan BNIAID NIH HHS11892-900https://www.ebi.ac.uk/biostudies/studies/S-EPMC1212604biostudies-literatureUnknown79(18)Massive numbers of palm civets were culled to remove sources for the reemergence of severe acute respiratory syndrome (SARS) in Guangdong Province, China, in January 2004, following SARS coronavirus detection in market animals. The virus was identified in all 91 palm civets and 15 raccoon dogs of animal market origin sampled prior to culling, but not in 1,107 palm civets later sampled at 25 farms, spread over 12 provinces, which were claimed to be the source of traded animals. Twenty-seven novel signature variation residues (SNVs) were identified on the spike gene and were analyzed for their phylogenetic relationships, based on 17 sequences obtained from animals in our study and from other published studies. Analysis indicated that the virus in palm civets at the live-animal market had evoJournal of virologyMolecular evolution analysis and geographic investigation of severe acute respiratory syndrome coronavirus-like virus in palm civets at an animal market and on farms.PMC1212604U19 AI051915U19 AI51915Jing HZhang ELiang WZou XZHai RLiu QYu DWang HZhao YTWang MFeng YJZheng HKan BQi XJiang XWan KCui BYan MLi GChen KGao YFXu HLi MXu JGuan YGao KCui ZDu LXu YYe JfalseMolecular evolution analysis and geographic investigation of severe acute respiratory syndrome coronavirus-like virus in palm civets at an animal market and on farms.Massive numbers of palm civets were culled to remove sources for the reemergence of severe acute respiratory syndrome (SARS) in Guangdong Province, China, in January 2004, following SARS coronavirus detection in market animals. The virus was identified in all 91 palm civets and 15 raccoon dogs of animal market origin sampled prior to culling, but not in 1,107 palm civets later sampled at 25 farms, spread over 12 provinces, which were claimed to be the source of traded animals. Twenty-seven novel signature variation residues (SNVs) were identified on the spike gene and were analyzed for their phylogenetic relationships, based on 17 sequences obtained from animals in our study and from other published studies. Analysis indicated that the virus in palm civets at the live-animal market had evo2005-01-01T00:00:00Z2005 Sep2026-05-29T23:06:13.969Z2019-03-27T01:09:24ZS-EPMC12126041614076510.1128/jvi.79.18.11892-11900.200510.1128/JVI.79.18.11892-11900.2005