biostudies-literatureUnknown36(5)Lisotti A<h4>Objectives</h4>Repeated endoscopic ultrasound (EUS)-guided tissue acquisition represents the standard practice for solid pancreatic lesions after previous nondiagnostic or inconclusive results. Since data are lacking, we aimed to evaluate the diagnostic performance of repeated EUS fine-needle biopsy (rEUS-FNB) in this setting. The primary outcome was diagnostic accuracy; sample adequacy, sensitivity, specificity, and safety were secondary outcomes.<h4>Methods</h4>Consecutive patients undergoing rEUS-FNB for solid pancreatic lesions at 23 Italian centers from 2019 to 2021 were retrieved. Pathology on the surgical specimen, malignant histology together with ≥6-month follow-up, and benign pathology together with ≥12-month follow-up were adopted as gold standards.<h4>Results</h4>Among 462 Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society615-624https://www.ebi.ac.uk/biostudies/studies/S-EPMC12136261biostudies-literatureRepeated endoscopic ultrasound-guided fine-needle biopsy of solid pancreatic lesions after previous nondiagnostic or inconclusive sampling.PMC12136261Mangiavillano BBinda CGasparini EOppezzi MConigliaro RMuscatiello NStigliano SPetrone MCLovero RAnderloni AMontale ADi Matteo FMLarghi ARizzatti GGrillo AArena RConti Bellocchi MCD'Errico FFabbri SDecembrino FGabbani TBarresi LTripodi GLisotti ATamanini GMasciangelo GMangiafico SFugazza ATogliani TREUBIO Study GroupDe Angelis CPezzoli ASolimando RMutignani MLupo MBertani HMerighi ACominardi AAragona GVannella GLega SSassatelli RTacelli MCalvanese CMarocchi GMirante VGColuccio CFabbri CCarrara SArchibugi LDabizzi EMasetti MPisani AMussetto AForti EGrande GPuccetti MBrighi NBurattini OZaccari PSignoretti MPellegrino MGBrancaccio MFacciorusso ASpadaccini MManno MDall'Amico EFantin AFusaroli PAmato AArcidiacono PGMaestri ACrino SFCecinato PZagari RMTelesca DAAntonini FfalseRepeated endoscopic ultrasound-guided fine-needle biopsy of solid pancreatic lesions after previous nondiagnostic or inconclusive sampling.<h4>Objectives</h4>Repeated endoscopic ultrasound (EUS)-guided tissue acquisition represents the standard practice for solid pancreatic lesions after previous nondiagnostic or inconclusive results. Since data are lacking, we aimed to evaluate the diagnostic performance of repeated EUS fine-needle biopsy (rEUS-FNB) in this setting. The primary outcome was diagnostic accuracy; sample adequacy, sensitivity, specificity, and safety were secondary outcomes.<h4>Methods</h4>Consecutive patients undergoing rEUS-FNB for solid pancreatic lesions at 23 Italian centers from 2019 to 2021 were retrieved. Pathology on the surgical specimen, malignant histology together with ≥6-month follow-up, and benign pathology together with ≥12-month follow-up were adopted as gold standards.<h4>Results</h4>Among 462 2024-01-01T00:00:00Z2024 May2026-06-02T01:11:50.293Z2026-05-24T03:07:39.955ZS-EPMC121362613771290610.1111/den.14686