{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["132(8)"],"submitter":["Nair M"],"funding":["British Heart Foundation","Medical Research Council","National Institute for Health and Care Research Applied Research Collaboration Oxford and Thames Valley"],"pubmed_abstract":["<h4>Objective</h4>Assessment of whether maternal anaemia in early pregnancy is associated with offspring congenital heart disease (CHD).<h4>Design</h4>Matched case-control study.<h4>Setting</h4>January 1998-October 2020, United Kingdom.<h4>Population</h4>Women with a haemoglobin measurement in the first 100 days of pregnancy and a CHD-diagnosed child.<h4>Methods</h4>Data were extracted from the United Kingdom Clinical Practice Research Datalink GOLD database of electronic health records. Cases were 2,776 women with a CHD-diagnosed child. These were compared to 13 880 matched controls, women without a CHD-diagnosed child. Anaemia was classified as < 110 g/L haemoglobin following the WHO definition. A conditional logistic regression analysis was conducted, adjusted for potential maternal demographic and health-related confounders.<h4>Main outcome measures</h4>Offspring CHD diagnosed within 5 years of birth.<h4>Results</h4>123 (4.4%) cases and 390 (2.8%) controls had anaemia. After adjusting for potential confounders, the odds of giving birth to a CHD-diagnosed child were 47% higher among anaemic mothers (adjusted OR 1.47, 95% CI 1.18,1.83, p < 0.001).<h4>Conclusions</h4>The observed association between maternal anaemia in early pregnancy and increased risk of offspring CHD supports our recent evidence in mice. Approximately two-thirds of anaemia cases globally are due to iron deficiency. A clinical trial of periconceptional iron supplementation might be a minimally invasive and low-cost intervention for the prevention of some CHD if iron deficiency anaemia is proven to be a cause."],"journal":["BJOG : an international journal of obstetrics and gynaecology"],"pagination":["1139-1146"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12137751"],"repository":["biostudies-literature"],"pubmed_title":["Maternal Anaemia and Congenital Heart Disease in Offspring: A Case-Control Study Using Linked Electronic Health Records in the United Kingdom."],"pmcid":["PMC12137751"],"pubmed_authors":["Sparrow DB","Smith M","Bankhead CR","Nair M","Drakesmith CW"],"additional_accession":[]},"is_claimable":false,"name":"Maternal Anaemia and Congenital Heart Disease in Offspring: A Case-Control Study Using Linked Electronic Health Records in the United Kingdom.","description":"<h4>Objective</h4>Assessment of whether maternal anaemia in early pregnancy is associated with offspring congenital heart disease (CHD).<h4>Design</h4>Matched case-control study.<h4>Setting</h4>January 1998-October 2020, United Kingdom.<h4>Population</h4>Women with a haemoglobin measurement in the first 100 days of pregnancy and a CHD-diagnosed child.<h4>Methods</h4>Data were extracted from the United Kingdom Clinical Practice Research Datalink GOLD database of electronic health records. Cases were 2,776 women with a CHD-diagnosed child. These were compared to 13 880 matched controls, women without a CHD-diagnosed child. Anaemia was classified as < 110 g/L haemoglobin following the WHO definition. A conditional logistic regression analysis was conducted, adjusted for potential maternal demographic and health-related confounders.<h4>Main outcome measures</h4>Offspring CHD diagnosed within 5 years of birth.<h4>Results</h4>123 (4.4%) cases and 390 (2.8%) controls had anaemia. After adjusting for potential confounders, the odds of giving birth to a CHD-diagnosed child were 47% higher among anaemic mothers (adjusted OR 1.47, 95% CI 1.18,1.83, p < 0.001).<h4>Conclusions</h4>The observed association between maternal anaemia in early pregnancy and increased risk of offspring CHD supports our recent evidence in mice. Approximately two-thirds of anaemia cases globally are due to iron deficiency. A clinical trial of periconceptional iron supplementation might be a minimally invasive and low-cost intervention for the prevention of some CHD if iron deficiency anaemia is proven to be a cause.","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jul","modification":"2026-05-29T16:32:53.278Z","creation":"2025-07-26T03:06:33.125Z"},"accession":"S-EPMC12137751","cross_references":{"pubmed":["40264354"],"doi":["10.1111/1471-0528.18150"]}}