{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Risner A"],"funding":["NCATS NIH HHS","NIDDK NIH HHS","NCI NIH HHS","NIGMS NIH HHS"],"pubmed_abstract":["Reactivation of transposable elements (TEs) in somatic tissues, particularly of LINE-1, is associated with disease by causing gene mutations and DNA damage. Previous work has shown that the PIWI pathway is crucial for TE suppression in the germline. However, the status and function of this pathway is not well characterized in differentiated somatic cells and there is lack of consensus on the role of the pathway in somatic tumorigenesis. To shed light on this conundrum, we examined the PIWI pathway in colon cancer through combining bioinformatic analyses and cell-based assays. Shifted Weighted Annotation Network (SWAN) analysis revealed that the pathway experiences significant allelic losses in colon cancer and that PIWIL2, the main catalytic component of the pathway responsible for TE sile"],"journal":["bioRxiv : the preprint server for biology"],"pagination":["2025.05.20.655197"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12139840"],"repository":["biostudies-literature"],"pubmed_title":["PIWIL2 downregulation in colon cancer promotes transposon activity and pro-tumorigenic phenotypes."],"pmcid":["PMC12139840"],"funding_grant_id":["R21 CA246233","UL1 TR001450","T32 DK124191","R01 DK136658","F31 DK138780","TL1 TR001451","P20 GM130457","DP2 CA280626","R01 DK124553","P30 DK123704"],"pubmed_authors":["Gangaraju V","Delaney JR","Cheedipudi A","Risner A","Kourtidis A","Nair-Menon J"],"additional_accession":[]},"is_claimable":false,"name":"PIWIL2 downregulation in colon cancer promotes transposon activity and pro-tumorigenic phenotypes.","description":"Reactivation of transposable elements (TEs) in somatic tissues, particularly of LINE-1, is associated with disease by causing gene mutations and DNA damage. Previous work has shown that the PIWI pathway is crucial for TE suppression in the germline. However, the status and function of this pathway is not well characterized in differentiated somatic cells and there is lack of consensus on the role of the pathway in somatic tumorigenesis. To shed light on this conundrum, we examined the PIWI pathway in colon cancer through combining bioinformatic analyses and cell-based assays. Shifted Weighted Annotation Network (SWAN) analysis revealed that the pathway experiences significant allelic losses in colon cancer and that PIWIL2, the main catalytic component of the pathway responsible for TE sile","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jul","modification":"2026-04-08T18:37:14.317Z","creation":"2025-08-14T03:05:42.353Z"},"accession":"S-EPMC12139840","cross_references":{"pubmed":["40475606"],"doi":["10.1101/2025.05.20.655197"]}}