{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lian X"],"funding":["National Natural Science Foundation of China","Climbing Project for Medical Talent of Zhongnan Hospital of Wuhan University","Noncommunicable Chronic Diseases-National Science and Technology"],"pagination":["bbaf266"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12145228"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["26(3)"],"pubmed_abstract":["Depicting a global landscape of essential gene-targeting drugs would provide more opportunities for cancer therapy. However, a systematic investigation on drugs targeting essential genes still has not been reported. We suppose that drugs targeting cancer-type-specific essential genes would generally have less toxicity than those targeting pan-cancer essential genes. A scoring function-based strategy was developed to identify cancer-type-specific targets and drugs. The EssentialitySpecificityScore ranked the essential genes in 19 cancer types, and 1151 top genes were identified as cancer-type-specific targets. Combining target-drug interaction databases with research/marketing status, 370 cancer-type-specific drugs were identified, bound to 100 out of all identified targets. Profiles of app"],"journal":["Briefings in bioinformatics"],"pubmed_title":["Systematic identification of cancer-type-specific drugs based on essential genes and validations in lung adenocarcinoma."],"pmcid":["PMC12145228"],"funding_grant_id":["2023ZD0506200","32370696","PDJH202406 and PDJH202205"],"pubmed_authors":["Cui HT","Zhang DD","Ye A","Guo HX","Lian X","Xu Q","Kuang X","Hao GF","Cheng Z","Guo FB","Liu Y","Wang CY","Zhang JY"],"additional_accession":[]},"is_claimable":false,"name":"Systematic identification of cancer-type-specific drugs based on essential genes and validations in lung adenocarcinoma.","description":"Depicting a global landscape of essential gene-targeting drugs would provide more opportunities for cancer therapy. However, a systematic investigation on drugs targeting essential genes still has not been reported. We suppose that drugs targeting cancer-type-specific essential genes would generally have less toxicity than those targeting pan-cancer essential genes. A scoring function-based strategy was developed to identify cancer-type-specific targets and drugs. The EssentialitySpecificityScore ranked the essential genes in 19 cancer types, and 1151 top genes were identified as cancer-type-specific targets. Combining target-drug interaction databases with research/marketing status, 370 cancer-type-specific drugs were identified, bound to 100 out of all identified targets. Profiles of app","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 May","modification":"2026-06-02T22:25:45.809Z","creation":"2026-04-21T03:13:35.777Z"},"accession":"S-EPMC12145228","cross_references":{"pubmed":["40483547"],"doi":["10.1093/bib/bbaf266"]}}