biostudies-literatureWang YNational Key Research and Development Program of China209https://www.ebi.ac.uk/biostudies/studies/S-EPMC12147359biostudies-literatureUnknown24(1)<h4>Background</h4>Duchenne muscular dystrophy (DMD) is a serious, progressive neuromuscular condition that predominantly impacts male individuals, marked by progressive muscle weakness resulting from mutations in the dystrophin gene (DMD) encoding dystrophin. DMD is a primary muscle disorder that often presents with secondary abnormalities in lipid metabolism and decreased bone mineral density. Although disturbances in circulating lipid profiles and skeletal health have been observed in individuals with DMD, their relationship remains underexplored.This study aimed to investigate the potential association between lipid metabolic disturbances and spinal bone mineral density in patients with DMD by combining clinical lipid levels and bone density with transcriptomic pathway analysis of DMD Lipids in health and diseaseAssociation between triglycerides and remnant cholesterol levels and spine bone mineral density in Duchenne muscular dystrophy.PMC121473592022YFC2703601Zheng ZWu SWang YZhang SChang YZhang PAi XfalseAssociation between triglycerides and remnant cholesterol levels and spine bone mineral density in Duchenne muscular dystrophy.<h4>Background</h4>Duchenne muscular dystrophy (DMD) is a serious, progressive neuromuscular condition that predominantly impacts male individuals, marked by progressive muscle weakness resulting from mutations in the dystrophin gene (DMD) encoding dystrophin. DMD is a primary muscle disorder that often presents with secondary abnormalities in lipid metabolism and decreased bone mineral density. Although disturbances in circulating lipid profiles and skeletal health have been observed in individuals with DMD, their relationship remains underexplored.This study aimed to investigate the potential association between lipid metabolic disturbances and spinal bone mineral density in patients with DMD by combining clinical lipid levels and bone density with transcriptomic pathway analysis of DMD 2025-01-01T00:00:00Z2025 Jun2026-06-03T07:39:29.598Z2026-04-26T03:09:39.165ZS-EPMC121473594049073910.1186/s12944-025-02628-0