{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wang G"],"funding":["National Natural Science Foundation of China","Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences"],"pagination":["85-95"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12147602"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["72"],"pubmed_abstract":["<h4>Introduction</h4>Ochratoxins (OTs) are worldwide regulated mycotoxins contaminating a variety of food-environment and agro-environment. Several Aspergillus and Pencillium species synthesize OTs from a six-gene biosynthetic gene cluster (BGC) to produce the highly toxic final product OTA. Although many studies on OTA-degrading enzymes were performed, high efficiency enzymes with strong stability are extremely needed, and the OTA degrading mechanism is poorly understood.<h4>Objectives</h4>The study aimed to explore the OT-degradation enzyme and investigate its degradation mechanisms in Metarhizium, which contain an OT biosynthetic gene cluster.<h4>Methods</h4>Phylogenomic relationship combined with RNA expression analysis were used to explore the distribution of OT BGC in fungi. Bioactiv"],"journal":["Journal of advanced research"],"pubmed_title":["Metarhizium spp. encode an ochratoxin cluster and a high efficiency ochratoxin-degrading amidohydrolase revealed by genomic analysis."],"pmcid":["PMC12147602"],"funding_grant_id":["CAAS-ZDRW202414","32372456"],"pubmed_authors":["Xing F","Guo X","Li E","Keller NP","Wang G","Ma J","Wu W"],"additional_accession":[]},"is_claimable":false,"name":"Metarhizium spp. encode an ochratoxin cluster and a high efficiency ochratoxin-degrading amidohydrolase revealed by genomic analysis.","description":"<h4>Introduction</h4>Ochratoxins (OTs) are worldwide regulated mycotoxins contaminating a variety of food-environment and agro-environment. Several Aspergillus and Pencillium species synthesize OTs from a six-gene biosynthetic gene cluster (BGC) to produce the highly toxic final product OTA. Although many studies on OTA-degrading enzymes were performed, high efficiency enzymes with strong stability are extremely needed, and the OTA degrading mechanism is poorly understood.<h4>Objectives</h4>The study aimed to explore the OT-degradation enzyme and investigate its degradation mechanisms in Metarhizium, which contain an OT biosynthetic gene cluster.<h4>Methods</h4>Phylogenomic relationship combined with RNA expression analysis were used to explore the distribution of OT BGC in fungi. Bioactiv","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jun","modification":"2026-06-03T07:31:18.742Z","creation":"2026-04-26T03:09:30.582Z"},"accession":"S-EPMC12147602","cross_references":{"pubmed":["39089618"],"doi":["10.1016/j.jare.2024.07.023"]}}