{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Agarwal R"],"funding":["NIAID NIH HHS"],"pagination":["102134"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12147901"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["6(5)"],"pubmed_abstract":["Chikungunya virus (CHIKV) is a mosquito-borne virus that can cause chronic chikungunya virus disease (CHIKVD), which is characterized by persistent incapacitating arthralgia. Despite recurring CHIKV outbreaks and recent approval of a vaccine, the breadth and target of T cell responses in CHIKVD remain largely understudied. Here, we tested peripheral blood mononuclear cells (PBMCs) collected from CHIKV-infected individuals against overlapping peptide pools sequentially spanning the entire CHIKV proteome. We detected robust CHIKV-specific CD4<sup>+</sup>, but not CD8<sup>+</sup>, T cell responses in infected individuals. Individuals with chronic arthralgia displayed significantly higher CD4<sup>+</sup> T cell responses against nsP1, nsP2, and E2 proteins and exhibited a significantly lower T"],"journal":["Cell reports. Medicine"],"pubmed_title":["Chikungunya virus-specific CD4&lt;sup&gt;+&lt;/sup&gt; T cells are associated with chronic chikungunya viral arthritic disease in humans."],"pmcid":["PMC12147901"],"funding_grant_id":["75N93019C00065","U24 AI152170"],"pubmed_authors":["Sette A","Agarwal R","Falconar AK","Premkumar L","Cortes FH","Galvez RI","Grifoni A","Heise MT","Weiskopf D","Castillo IN","Romero-Vivas CM","Villalpando J","Chang J","Ha C"],"additional_accession":[]},"is_claimable":false,"name":"Chikungunya virus-specific CD4&lt;sup&gt;+&lt;/sup&gt; T cells are associated with chronic chikungunya viral arthritic disease in humans.","description":"Chikungunya virus (CHIKV) is a mosquito-borne virus that can cause chronic chikungunya virus disease (CHIKVD), which is characterized by persistent incapacitating arthralgia. Despite recurring CHIKV outbreaks and recent approval of a vaccine, the breadth and target of T cell responses in CHIKVD remain largely understudied. Here, we tested peripheral blood mononuclear cells (PBMCs) collected from CHIKV-infected individuals against overlapping peptide pools sequentially spanning the entire CHIKV proteome. We detected robust CHIKV-specific CD4<sup>+</sup>, but not CD8<sup>+</sup>, T cell responses in infected individuals. Individuals with chronic arthralgia displayed significantly higher CD4<sup>+</sup> T cell responses against nsP1, nsP2, and E2 proteins and exhibited a significantly lower T","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 May","modification":"2026-04-25T03:22:08.702Z","creation":"2026-04-25T03:20:34.494Z"},"accession":"S-EPMC12147901","cross_references":{"pubmed":["40398392"],"doi":["10.1016/j.xcrm.2025.102134"]}}