biostudies-literatureUnknown6(5)Zheng CHWe report the short-term results of indocyanine green (ICG)-guided laparoscopic lymphadenectomy for gastric cancer (GC). The primary outcome is 3-year disease-free survival. In this analysis, we present short-term secondary outcomes focused on the number of lymph nodes (LNs) retrieved and the diagnostic value of fluorescent status for metastatic LNs, excluding long-term outcomes. A total of 1,006 patients are included in the per-protocol analysis. The mean number of LNs retrieved in the ICG group is significantly higher than that in the non-ICG group. The negative predictive value is 93.9% for nonfluorescent stations, and the sensitivity of ICG for detecting all metastatic LN stations is 91.6%. ICG technology is safe and feasible for laparoscopic lymphadenectomy in GC and can noticeably inCell reports. Medicine102136https://www.ebi.ac.uk/biostudies/studies/S-EPMC12147906biostudies-literatureSafety and efficacy of indocyanine green-guided laparoscopic lymphadenectomy for locally advanced gastric cancer: The CLASS-11 clinical trials.PMC12147906Chen YBSun YHLiang YCai LSQiu HBLiu ZYLi GXHuang CMSu XQWei MHuo BWWang QXu ZKXie JWJi JFChinese Laparoscopic Gastrointestinal Surgery Study (CLASS) GroupXu YCChen QYChen QXWang BGLi CLi PYan SYan ZBZeng LXLv CBHe XLZhong QYu WBLi SLiu ZMTian YTZheng CHLi ZYfalseSafety and efficacy of indocyanine green-guided laparoscopic lymphadenectomy for locally advanced gastric cancer: The CLASS-11 clinical trials.We report the short-term results of indocyanine green (ICG)-guided laparoscopic lymphadenectomy for gastric cancer (GC). The primary outcome is 3-year disease-free survival. In this analysis, we present short-term secondary outcomes focused on the number of lymph nodes (LNs) retrieved and the diagnostic value of fluorescent status for metastatic LNs, excluding long-term outcomes. A total of 1,006 patients are included in the per-protocol analysis. The mean number of LNs retrieved in the ICG group is significantly higher than that in the non-ICG group. The negative predictive value is 93.9% for nonfluorescent stations, and the sensitivity of ICG for detecting all metastatic LN stations is 91.6%. ICG technology is safe and feasible for laparoscopic lymphadenectomy in GC and can noticeably in2025-01-01T00:00:00Z2025 May2026-06-03T05:52:03.457Z2026-04-25T03:16:26.947ZS-EPMC121479064039838810.1016/j.xcrm.2025.102136