biostudies-literatureUnknown116Hahner S<h4>Background</h4>Adrenal tumours are frequently detected by conventional imaging. However, computed tomography and magnet resonance imaging have limited specificity in classifying the most prevalent tumour type, adrenocortical adenoma (ACA), which typically does not require surgery. We proposed that combined molecular imaging with [¹⁸F]Fluorodeoxyglucose-positron emission tomography (FDG PET) and [^123I]Iodometomidate-single photon emission tomography (IMTO SPECT) improves non-invasive classification of ACA.<h4>Methods</h4>This cross-sectional, multicentre diagnostic study included patients (≥30 years) with non-functioning indeterminate adrenal masses (>3 cm or increase >1 cm, Hounsfield units [HU] ≥10 on unenhanced computed tomography [CT]) scheduled for surgery. UsEBioMedicine105735https://www.ebi.ac.uk/biostudies/studies/S-EPMC12148602biostudies-literatureCombined [&lt;sup&gt;18&lt;/sup&gt;F]Fluorodeoxyglucose PET and [&lt;sup&gt;123&lt;/sup&gt;I]Iodometomidate-SPECT for diagnostic evaluation of indeterminate adrenal neoplasias-the cross-sectional diagnostic test accuracy study FAMIAN.PMC12148602Lincke TSaeger WFuß CTSandner BMai KReibetanz JSchlotelburg WGrasl MBeuschlein FTonjes AKonrad Buck AMiederer MSabri OWerner JQuinkler MHartrampf PHerrmann KWeber MReuter MFAMIAN investigatorsSchreckenberger MMuller HHSchirbel AWeber FMiehle KFurth CFottner CPfluger TArlt WAmthauer HFassnacht MReincke MHahner SDralle HKluge RRayes NKircher SfalseCombined [&lt;sup&gt;18&lt;/sup&gt;F]Fluorodeoxyglucose PET and [&lt;sup&gt;123&lt;/sup&gt;I]Iodometomidate-SPECT for diagnostic evaluation of indeterminate adrenal neoplasias-the cross-sectional diagnostic test accuracy study FAMIAN.<h4>Background</h4>Adrenal tumours are frequently detected by conventional imaging. However, computed tomography and magnet resonance imaging have limited specificity in classifying the most prevalent tumour type, adrenocortical adenoma (ACA), which typically does not require surgery. We proposed that combined molecular imaging with [¹⁸F]Fluorodeoxyglucose-positron emission tomography (FDG PET) and [^123I]Iodometomidate-single photon emission tomography (IMTO SPECT) improves non-invasive classification of ACA.<h4>Methods</h4>This cross-sectional, multicentre diagnostic study included patients (≥30 years) with non-functioning indeterminate adrenal masses (>3 cm or increase >1 cm, Hounsfield units [HU] ≥10 on unenhanced computed tomography [CT]) scheduled for surgery. Us2025-01-01T00:00:00Z2025 Jun2026-06-01T15:57:33.167Z2026-04-08T13:58:10.86ZS-EPMC121486024039835010.1016/j.ebiom.2025.105735