{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["16"],"submitter":["Griesbaum L"],"pubmed_abstract":["Introduction
As a part of the innate immune system, eosinophils are recruited during infectious diseases, to release their characteristic cytotoxic granules and catch pathogens in extracellular traps. Moreover, eosinophils have a crucial role in autoimmune diseases, for example allergies. The isolation of these densest and lowest abundant leukocytes is cost-and labor intense. This sets restrictions on many aspects of eosinophilic research. In this study, we performed a thorough characterization and functional assessment of the HL-60 clone 15 (HC15) cell line, which can be differentiated into eosinophil-like cells, to investigate its potential in eosinophil research.Methods
HC15 cells were differentiated with sodium butyrate with or without IL-5 and cells were characterized "],"journal":["Frontiers in immunology"],"pagination":["1515993"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12148902"],"repository":["biostudies-literature"],"pubmed_title":["The HL-60 clone 15 cell line as a model for leukocyte migration-possibilities and limitations."],"pmcid":["PMC12148902"],"pubmed_authors":["Griesbaum L","Weusthof C","Klimek L","Sauer T","Gemoll T","Petry J","Bashiri Dezfouli A","Shoykhet M","Weirich G","Wollenberg B"],"additional_accession":[]},"is_claimable":false,"name":"The HL-60 clone 15 cell line as a model for leukocyte migration-possibilities and limitations.","description":"Introduction
As a part of the innate immune system, eosinophils are recruited during infectious diseases, to release their characteristic cytotoxic granules and catch pathogens in extracellular traps. Moreover, eosinophils have a crucial role in autoimmune diseases, for example allergies. The isolation of these densest and lowest abundant leukocytes is cost-and labor intense. This sets restrictions on many aspects of eosinophilic research. In this study, we performed a thorough characterization and functional assessment of the HL-60 clone 15 (HC15) cell line, which can be differentiated into eosinophil-like cells, to investigate its potential in eosinophil research.Methods
HC15 cells were differentiated with sodium butyrate with or without IL-5 and cells were characterized ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025","modification":"2026-06-02T20:31:32.469Z","creation":"2026-04-20T03:10:19.136Z"},"accession":"S-EPMC12148902","cross_references":{"pubmed":["40496865"],"doi":["10.3389/fimmu.2025.1515993"]}}