{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Tavares V"],"funding":["North Portugal Regional Operational Programme","European Union","Fundação para a Ciência e Tecnologia (FCT)","Portuguese League Against Cancer - Northern Branch (LPCC- NRN)","IPO-Porto Research Center"],"pagination":["663-678"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12149255"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["58(5)"],"pubmed_abstract":["Colorectal cancer (CRC) is the second leading cause of malignancy-related death worldwide, representing a significant health concern. Understanding the disease pathogenesis and identifying potential prognostic biomarkers is critical for improving patients' clinical outcomes. Haemostatic components implicated in cancer-associated thrombosis (CAT) seem to favour CRC progression. As such, genetic markers of thrombophilia might be potential prognostic biomarkers among patients with this malignant disease. To offer perspectives, a retrospective cohort study with 204 CRC patients was conducted to investigate the impact of seven germline haemostatic gene determinants on patient prognosis. A sex-stratified analysis was performed as the variants seem to have a distinct influence depending on the pa"],"journal":["Journal of thrombosis and thrombolysis"],"pubmed_title":["Genetic markers of thrombophilia as predictors of outcome in colorectal cancer."],"pmcid":["PMC12149255"],"funding_grant_id":["NORTE-01-0247-FEDER-033399","CI-IPO-21-2015","CI-IPOP-BI-99/2018 - BIL1","CI-IPOP-BI-99/2018 - BIL2","2020.08969.BD; https://doi.org/10.54499/2020.08969.BD","UI/BD/151488/2021","LPCC-NRN2025-VT","UIDB/00776/2020-3","101095359"],"pubmed_authors":["Dinis-Ribeiro M","Medeiros R","Pereira D","Lopes C","Pinelas S","Pereira C","Farinha M","Costa J","Vilas-Boas MI","Macedo-Silva C","Assis J","Tavares V"],"additional_accession":[]},"is_claimable":false,"name":"Genetic markers of thrombophilia as predictors of outcome in colorectal cancer.","description":"Colorectal cancer (CRC) is the second leading cause of malignancy-related death worldwide, representing a significant health concern. Understanding the disease pathogenesis and identifying potential prognostic biomarkers is critical for improving patients' clinical outcomes. Haemostatic components implicated in cancer-associated thrombosis (CAT) seem to favour CRC progression. As such, genetic markers of thrombophilia might be potential prognostic biomarkers among patients with this malignant disease. To offer perspectives, a retrospective cohort study with 204 CRC patients was conducted to investigate the impact of seven germline haemostatic gene determinants on patient prognosis. A sex-stratified analysis was performed as the variants seem to have a distinct influence depending on the pa","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jun","modification":"2026-06-03T06:34:15.563Z","creation":"2026-04-25T03:20:39.362Z"},"accession":"S-EPMC12149255","cross_references":{"pubmed":["40425987"],"doi":["10.1007/s11239-025-03106-1"]}}