biostudies-literatureTavares VNorth Portugal Regional Operational ProgrammeEuropean UnionFundação para a Ciência e Tecnologia (FCT)Portuguese League Against Cancer - Northern Branch (LPCC- NRN)IPO-Porto Research Center663-678https://www.ebi.ac.uk/biostudies/studies/S-EPMC12149255biostudies-literatureUnknown58(5)Colorectal cancer (CRC) is the second leading cause of malignancy-related death worldwide, representing a significant health concern. Understanding the disease pathogenesis and identifying potential prognostic biomarkers is critical for improving patients' clinical outcomes. Haemostatic components implicated in cancer-associated thrombosis (CAT) seem to favour CRC progression. As such, genetic markers of thrombophilia might be potential prognostic biomarkers among patients with this malignant disease. To offer perspectives, a retrospective cohort study with 204 CRC patients was conducted to investigate the impact of seven germline haemostatic gene determinants on patient prognosis. A sex-stratified analysis was performed as the variants seem to have a distinct influence depending on the paJournal of thrombosis and thrombolysisGenetic markers of thrombophilia as predictors of outcome in colorectal cancer.PMC12149255NORTE-01-0247-FEDER-033399CI-IPO-21-2015CI-IPOP-BI-99/2018 - BIL1CI-IPOP-BI-99/2018 - BIL22020.08969.BD; https://doi.org/10.54499/2020.08969.BDUI/BD/151488/2021LPCC-NRN2025-VTUIDB/00776/2020-3101095359Dinis-Ribeiro MMedeiros RPereira DLopes CPinelas SPereira CFarinha MCosta JVilas-Boas MIMacedo-Silva CAssis JTavares VfalseGenetic markers of thrombophilia as predictors of outcome in colorectal cancer.Colorectal cancer (CRC) is the second leading cause of malignancy-related death worldwide, representing a significant health concern. Understanding the disease pathogenesis and identifying potential prognostic biomarkers is critical for improving patients' clinical outcomes. Haemostatic components implicated in cancer-associated thrombosis (CAT) seem to favour CRC progression. As such, genetic markers of thrombophilia might be potential prognostic biomarkers among patients with this malignant disease. To offer perspectives, a retrospective cohort study with 204 CRC patients was conducted to investigate the impact of seven germline haemostatic gene determinants on patient prognosis. A sex-stratified analysis was performed as the variants seem to have a distinct influence depending on the pa2025-01-01T00:00:00Z2025 Jun2026-06-03T06:34:15.563Z2026-04-25T03:20:39.362ZS-EPMC121492554042598710.1007/s11239-025-03106-1