{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Peter C"],"funding":["NIA NIH HHS"],"pagination":["825-836"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12150229"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["82(8)"],"pubmed_abstract":["<h4>Importance</h4>There has yet to be a large-scale study quantifying the association between white matter microstructure and cognitive performance and decline in aging and Alzheimer disease (AD).<h4>Objective</h4>To investigate the associations between tract-specific white matter microstructure and cognitive performance and decline in aging and AD-related cognitive impairment.<h4>Design setting and participants</h4>This prognostic study of aging and AD, a secondary data analysis of multisite cohort studies, acquired data from 9 cohorts between September 2002 and November 2022. Participants were eligible if they had diffusion-weighted magnetic resonance imaging (dMRI) data, domain-specific cognitive composite <i>z</i> scores, demographic and clinical data, were aged 50 years or older, and"],"journal":["JAMA neurology"],"pubmed_title":["White Matter Abnormalities and Cognition in Aging and Alzheimer Disease."],"pmcid":["PMC12150229"],"funding_grant_id":["R01 AG080821","R01 AG085571","R01 AG034962","R01 AG083865"],"pubmed_authors":["Mez J","Scollard P","Wang D","Zaras D","Gao C","Zhang P","Cuccaro ML","Tosun-Turgut D","Gaynor LS","Davatzikos C","and the Alzheimer’s Disease Sequencing Project Phenotype Harmonization Consortium (ADSP-PHC) Analyst Team","Sathe A","Bolton CJ","Durant A","Habes M","Crane PK","Beason-Held LL","Yao T","Erus G","Ramadass K","Bendlin BB","Hohman TJ","Schilling KG","Yang Y","Li Z","Huo Y","Shashikumar N","Mukherjee S","Thompson PM","Lee ML","Pechman KR","Kukull W","Barnes LL","Arfanakis K","Jefferson AL","Newlin NR","Toga AW","Dumitrescu LC","Peter C","Johnson SC","Risacher SL","An Y","Biber SA","Resnick SM","Kim ME","Saykin AJ","Landman BA","Khairi NM","Klinedinst B","Workmeister AW","Kanakaraj P","Schneider J","Albert M","Archer DB","Bennett DA","Gifford KA","Choi SE","Jackson TB","Sanders EA","Trittschuh EH"],"additional_accession":[]},"is_claimable":false,"name":"White Matter Abnormalities and Cognition in Aging and Alzheimer Disease.","description":"<h4>Importance</h4>There has yet to be a large-scale study quantifying the association between white matter microstructure and cognitive performance and decline in aging and Alzheimer disease (AD).<h4>Objective</h4>To investigate the associations between tract-specific white matter microstructure and cognitive performance and decline in aging and AD-related cognitive impairment.<h4>Design setting and participants</h4>This prognostic study of aging and AD, a secondary data analysis of multisite cohort studies, acquired data from 9 cohorts between September 2002 and November 2022. Participants were eligible if they had diffusion-weighted magnetic resonance imaging (dMRI) data, domain-specific cognitive composite <i>z</i> scores, demographic and clinical data, were aged 50 years or older, and","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Aug","modification":"2026-05-04T18:48:35.322Z","creation":"2026-04-07T20:47:50.848Z"},"accession":"S-EPMC12150229","cross_references":{"pubmed":["40513084"],"doi":["10.1001/jamaneurol.2025.1601"]}}