{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Feng R"],"funding":["NINDS NIH HHS","NIH HHS"],"pubmed_abstract":["Peripheral sensory neurons regenerate their axons after injury to regain function, but this ability declines with age. The mechanisms behind this decline are not fully understood. While excessive production of endothelin 1 (ET-1), a potent vasoconstrictor, is linked to many diseases that increase with age, the role of ET-1 and its receptors in axon regeneration is unknown. Using single cell RNA sequencing, we show that satellite glial cells (SGCs), which completely envelop the sensory neuron soma residing in the dorsal root ganglia (DRG), express the endothelin B receptor (ETBR), while ET-1 is expressed by endothelial cells. Inhibition of ETBR <i>ex-vivo</i> in DRG explant cultures improves axon growth in both adult and aged conditions. <i>In vivo</i>, treatment with the FDA-approved compo"],"journal":["bioRxiv : the preprint server for biology"],"pagination":["2024.06.08.597928"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12157355"],"repository":["biostudies-literature"],"pubmed_title":["Endothelin B receptor inhibition rescues aging-dependent neuronal regenerative decline."],"pmcid":["PMC12157355"],"funding_grant_id":["R35 NS122260","R21 NS115492","S10 OD032186","R01 NS111719"],"pubmed_authors":["Avraham O","Cavalli V","Thomsen MB","Rosen SF","Ansari I","Geoffroy CG","Feng R","John S"],"additional_accession":[]},"is_claimable":false,"name":"Endothelin B receptor inhibition rescues aging-dependent neuronal regenerative decline.","description":"Peripheral sensory neurons regenerate their axons after injury to regain function, but this ability declines with age. The mechanisms behind this decline are not fully understood. While excessive production of endothelin 1 (ET-1), a potent vasoconstrictor, is linked to many diseases that increase with age, the role of ET-1 and its receptors in axon regeneration is unknown. Using single cell RNA sequencing, we show that satellite glial cells (SGCs), which completely envelop the sensory neuron soma residing in the dorsal root ganglia (DRG), express the endothelin B receptor (ETBR), while ET-1 is expressed by endothelial cells. Inhibition of ETBR <i>ex-vivo</i> in DRG explant cultures improves axon growth in both adult and aged conditions. <i>In vivo</i>, treatment with the FDA-approved compo","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jun","modification":"2026-05-27T03:16:11.356Z","creation":"2026-05-27T03:07:39.504Z"},"accession":"S-EPMC12157355","cross_references":{"pubmed":["40501762"],"doi":["10.1101/2024.06.08.597928"]}}