{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wang Y"],"funding":["National Natural Science Foundation of China","Young Scientists Fund of the National Natural Science Foundation of China"],"pagination":["e70437"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12159765"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(6)"],"pubmed_abstract":["<h4>Background</h4>The phantom sound of tinnitus can be an extremely debilitating condition. The thalamocortical dysrhythmia (TCD) hypothesis is a feature of subjective tinnitus; however, its consistency in characterizing different types of tinnitus remains unclear.<h4>Method</h4>We compared theta-beta/gamma coupling in multichannel EEG recordings from subjects with bothersome tinnitus (BT), non-bothersome tinnitus (NBT), and healthy controls (HC). Additionally, we used these EEG features to distinguish BT from NBT by employing the k-nearest neighbor (KNN) model.<h4>Results</h4>Theta-beta/gamma phase-amplitude coupling (PAC) was enhanced in the auditory cortex of both BT and NBT groups compared to HC. In contrast, theta-beta/gamma PAC was specifically enhanced in the cingulate gyrus and pa"],"journal":["Brain and behavior"],"pubmed_title":["Theta-Beta/Gamma Coupling Identifies Bothersome Tinnitus Induced by Thalamocortical Dysrhythmia."],"pmcid":["PMC12159765"],"funding_grant_id":["82271161","82101220","82071041"],"pubmed_authors":["Huang S","Zhang J","Yin S","Huang X","Feng Y","Salvi R","Wang H","Wang Y","Shi H"],"additional_accession":[]},"is_claimable":false,"name":"Theta-Beta/Gamma Coupling Identifies Bothersome Tinnitus Induced by Thalamocortical Dysrhythmia.","description":"<h4>Background</h4>The phantom sound of tinnitus can be an extremely debilitating condition. The thalamocortical dysrhythmia (TCD) hypothesis is a feature of subjective tinnitus; however, its consistency in characterizing different types of tinnitus remains unclear.<h4>Method</h4>We compared theta-beta/gamma coupling in multichannel EEG recordings from subjects with bothersome tinnitus (BT), non-bothersome tinnitus (NBT), and healthy controls (HC). Additionally, we used these EEG features to distinguish BT from NBT by employing the k-nearest neighbor (KNN) model.<h4>Results</h4>Theta-beta/gamma phase-amplitude coupling (PAC) was enhanced in the auditory cortex of both BT and NBT groups compared to HC. In contrast, theta-beta/gamma PAC was specifically enhanced in the cingulate gyrus and pa","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jun","modification":"2026-06-06T15:11:11.72Z","creation":"2026-06-01T03:10:47.345Z"},"accession":"S-EPMC12159765","cross_references":{"pubmed":["40503593"],"doi":["10.1002/brb3.70437"]}}