biostudies-literatureWang YNational Natural Science Foundation of ChinaYoung Scientists Fund of the National Natural Science Foundation of Chinae70437https://www.ebi.ac.uk/biostudies/studies/S-EPMC12159765biostudies-literatureUnknown15(6)<h4>Background</h4>The phantom sound of tinnitus can be an extremely debilitating condition. The thalamocortical dysrhythmia (TCD) hypothesis is a feature of subjective tinnitus; however, its consistency in characterizing different types of tinnitus remains unclear.<h4>Method</h4>We compared theta-beta/gamma coupling in multichannel EEG recordings from subjects with bothersome tinnitus (BT), non-bothersome tinnitus (NBT), and healthy controls (HC). Additionally, we used these EEG features to distinguish BT from NBT by employing the k-nearest neighbor (KNN) model.<h4>Results</h4>Theta-beta/gamma phase-amplitude coupling (PAC) was enhanced in the auditory cortex of both BT and NBT groups compared to HC. In contrast, theta-beta/gamma PAC was specifically enhanced in the cingulate gyrus and paBrain and behaviorTheta-Beta/Gamma Coupling Identifies Bothersome Tinnitus Induced by Thalamocortical Dysrhythmia.PMC12159765822711618210122082071041Huang SZhang JYin SHuang XFeng YSalvi RWang HWang YShi HfalseTheta-Beta/Gamma Coupling Identifies Bothersome Tinnitus Induced by Thalamocortical Dysrhythmia.<h4>Background</h4>The phantom sound of tinnitus can be an extremely debilitating condition. The thalamocortical dysrhythmia (TCD) hypothesis is a feature of subjective tinnitus; however, its consistency in characterizing different types of tinnitus remains unclear.<h4>Method</h4>We compared theta-beta/gamma coupling in multichannel EEG recordings from subjects with bothersome tinnitus (BT), non-bothersome tinnitus (NBT), and healthy controls (HC). Additionally, we used these EEG features to distinguish BT from NBT by employing the k-nearest neighbor (KNN) model.<h4>Results</h4>Theta-beta/gamma phase-amplitude coupling (PAC) was enhanced in the auditory cortex of both BT and NBT groups compared to HC. In contrast, theta-beta/gamma PAC was specifically enhanced in the cingulate gyrus and pa2025-01-01T00:00:00Z2025 Jun2026-06-06T15:11:11.72Z2026-06-01T03:10:47.345ZS-EPMC121597654050359310.1002/brb3.70437