{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["16"],"submitter":["Lonardi S"],"pubmed_abstract":["<h4>Background</h4>The retinoic-acid-receptor-related orphan receptor gamma t (RORγt) isoform is required for the development of lymphoid organs, T-helper 17 cells (Th17), and innate lymphoid cells (ILC3s). Recent data in mouse and human have revealed non-T, non-ILC3 cell populations with antigen presenting features that express RORγt. This study maps the presence of RORγt cells with dendritic cell (DC) features in human adult and fetal lymphoid tissues.<h4>Methods</h4>By combining multicolor flow cytometry, RNAseq of peripheral blood cells, analysis of lymph node scRNAseq datasets, and microscopic analysis on human tissue sections and single-cell suspensions, this study maps the presence of RORγt cells with DC features in human tissues.<h4>Results</h4>RORγt-DCs are found in human lymphoid"],"journal":["Frontiers in immunology"],"pagination":["1527499"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12162286"],"repository":["biostudies-literature"],"pubmed_title":["Mapping of RORγt&lt;sup&gt;+&lt;/sup&gt; dendritic cells in human tissues establishes their preferential niche in adult lymph nodes."],"pmcid":["PMC12162286"],"pubmed_authors":["Bianchetto-Aguilera FM","Monti M","Missale F","Bugatti M","Antonova AU","Lonardi S","Ferrari G","Colonna M","Lorenzi L","Savoldi V","Cassatella MA","Di Matteo A","Zini S","Ghigna C","Cella M","Benedetti M","Facchetti F","Wu S","Agostini V","Picinoli S","Vermi W","Chiarini M","Liu YA","Moratto D"],"additional_accession":[]},"is_claimable":false,"name":"Mapping of RORγt&lt;sup&gt;+&lt;/sup&gt; dendritic cells in human tissues establishes their preferential niche in adult lymph nodes.","description":"<h4>Background</h4>The retinoic-acid-receptor-related orphan receptor gamma t (RORγt) isoform is required for the development of lymphoid organs, T-helper 17 cells (Th17), and innate lymphoid cells (ILC3s). Recent data in mouse and human have revealed non-T, non-ILC3 cell populations with antigen presenting features that express RORγt. This study maps the presence of RORγt cells with dendritic cell (DC) features in human adult and fetal lymphoid tissues.<h4>Methods</h4>By combining multicolor flow cytometry, RNAseq of peripheral blood cells, analysis of lymph node scRNAseq datasets, and microscopic analysis on human tissue sections and single-cell suspensions, this study maps the presence of RORγt cells with DC features in human tissues.<h4>Results</h4>RORγt-DCs are found in human lymphoid","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025","modification":"2026-05-26T20:10:27.086Z","creation":"2026-05-26T03:07:13.38Z"},"accession":"S-EPMC12162286","cross_references":{"pubmed":["40519913"],"doi":["10.3389/fimmu.2025.1527499"]}}