{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["27(6)"],"submitter":["Lara Gutierrez A"],"pubmed_abstract":["Genomic instability scars are markers for detecting homologous recombination deficiency (HRD) status in patients with ovarian cancer and predicting the response to poly (ADP-ribose) polymerase inhibitor treatment. Currently, only a few reliable and validated assays are available, with the Myriad myChoice CDx being the most commonly used commercial assay for genomic instability scar score determination. Given the need for a more straightforward, accessible, and reliable method for detecting genomic instability scars methods, in this work, we describe the feasibility of using the microarray OncoScan copy number variant assay and open-source software packages to quantify genomic instability scores, and the development of an open-access online platform for genomic instability score calculation"],"journal":["The Journal of molecular diagnostics : JMD"],"pagination":["475-484"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12163384"],"repository":["biostudies-literature"],"pubmed_title":["Robust Assessment of Homologous Recombination Deficiency Genomic Instability by OncoScan Microarrays."],"pmcid":["PMC12163384"],"pubmed_authors":["Peternell C","Kashofer K","Lara Gutierrez A","Regitnig P","Petru E","Halbwedl I","Bodo K","Prein K","Seebock R","Sauer S","Schubert S"],"additional_accession":[]},"is_claimable":false,"name":"Robust Assessment of Homologous Recombination Deficiency Genomic Instability by OncoScan Microarrays.","description":"Genomic instability scars are markers for detecting homologous recombination deficiency (HRD) status in patients with ovarian cancer and predicting the response to poly (ADP-ribose) polymerase inhibitor treatment. Currently, only a few reliable and validated assays are available, with the Myriad myChoice CDx being the most commonly used commercial assay for genomic instability scar score determination. Given the need for a more straightforward, accessible, and reliable method for detecting genomic instability scars methods, in this work, we describe the feasibility of using the microarray OncoScan copy number variant assay and open-source software packages to quantify genomic instability scores, and the development of an open-access online platform for genomic instability score calculation","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jun","modification":"2025-07-26T03:07:26.222Z","creation":"2025-07-26T03:07:26.222Z"},"accession":"S-EPMC12163384","cross_references":{"pubmed":["40188947"],"doi":["10.1016/j.jmoldx.2025.02.011"]}}