biostudies-literatureUnknown27(6)Lara Gutierrez AGenomic instability scars are markers for detecting homologous recombination deficiency (HRD) status in patients with ovarian cancer and predicting the response to poly (ADP-ribose) polymerase inhibitor treatment. Currently, only a few reliable and validated assays are available, with the Myriad myChoice CDx being the most commonly used commercial assay for genomic instability scar score determination. Given the need for a more straightforward, accessible, and reliable method for detecting genomic instability scars methods, in this work, we describe the feasibility of using the microarray OncoScan copy number variant assay and open-source software packages to quantify genomic instability scores, and the development of an open-access online platform for genomic instability score calculationThe Journal of molecular diagnostics : JMD475-484https://www.ebi.ac.uk/biostudies/studies/S-EPMC12163384biostudies-literatureRobust Assessment of Homologous Recombination Deficiency Genomic Instability by OncoScan Microarrays.PMC12163384Peternell CKashofer KLara Gutierrez ARegitnig PPetru EHalbwedl IBodo KPrein KSeebock RSauer SSchubert SfalseRobust Assessment of Homologous Recombination Deficiency Genomic Instability by OncoScan Microarrays.Genomic instability scars are markers for detecting homologous recombination deficiency (HRD) status in patients with ovarian cancer and predicting the response to poly (ADP-ribose) polymerase inhibitor treatment. Currently, only a few reliable and validated assays are available, with the Myriad myChoice CDx being the most commonly used commercial assay for genomic instability scar score determination. Given the need for a more straightforward, accessible, and reliable method for detecting genomic instability scars methods, in this work, we describe the feasibility of using the microarray OncoScan copy number variant assay and open-source software packages to quantify genomic instability scores, and the development of an open-access online platform for genomic instability score calculation2025-01-01T00:00:00Z2025 Jun2025-07-26T03:07:26.222Z2025-07-26T03:07:26.222ZS-EPMC121633844018894710.1016/j.jmoldx.2025.02.011