{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["195(5)"],"submitter":["Chanpanitkitchote P"],"pubmed_abstract":["Extracellular matrix (ECM) proteins play an important role in the pathological processes of tumor development and progression. Elastic microfibril interface located protein-1 (EMILIN-1), an ECM glycoprotein, is linked to cell adhesion and migration. It was identified from head and neck squamous cell carcinoma (HNSCC) tissues that down-regulated EMILIN-1. It is associated with an increased risk of secondary primary malignancy development in HNSCC and hypothesized to function as a tumor suppressor in HNSCC. This study showed that EMILIN-1 expression in HNSCC tissues was specific to the stromal area, and secreted-EMILIN-1 level was higher in fibroblasts isolated from HNSCC tissues than in HNSCC cells. EMILIN-1 overexpression decreased cell proliferation, migration, and invasion in FaDu and CA"],"journal":["The American journal of pathology"],"pagination":["995-1012"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12163418"],"repository":["biostudies-literature"],"pubmed_title":["EMILIN-1 Suppresses Cell Proliferation through Altered Cell Cycle Regulation in Head and Neck Squamous Cell Carcinoma."],"pmcid":["PMC12163418"],"pubmed_authors":["Mendler S","Nuanpirom J","Asavapanumas N","Pongsapich W","Wiesmann N","Jinawath N","Chanpanitkitchote P","Brieger J"],"additional_accession":[]},"is_claimable":false,"name":"EMILIN-1 Suppresses Cell Proliferation through Altered Cell Cycle Regulation in Head and Neck Squamous Cell Carcinoma.","description":"Extracellular matrix (ECM) proteins play an important role in the pathological processes of tumor development and progression. Elastic microfibril interface located protein-1 (EMILIN-1), an ECM glycoprotein, is linked to cell adhesion and migration. It was identified from head and neck squamous cell carcinoma (HNSCC) tissues that down-regulated EMILIN-1. It is associated with an increased risk of secondary primary malignancy development in HNSCC and hypothesized to function as a tumor suppressor in HNSCC. This study showed that EMILIN-1 expression in HNSCC tissues was specific to the stromal area, and secreted-EMILIN-1 level was higher in fibroblasts isolated from HNSCC tissues than in HNSCC cells. EMILIN-1 overexpression decreased cell proliferation, migration, and invasion in FaDu and CA","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 May","modification":"2026-06-01T23:22:27.484Z","creation":"2026-05-23T03:08:24.236Z"},"accession":"S-EPMC12163418","cross_references":{"pubmed":["39892781"],"doi":["10.1016/j.ajpath.2025.01.010"]}}