{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Li Y"],"funding":["National Natural Science Foundation of China","National Natural Science Foundation of China (NSFC)","National Key Research and Development Program of China (NKPs)","National Key Research and Development Program of China"],"pagination":["2495-2514"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12163602"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["31(12)"],"pubmed_abstract":["<h4>Purpose</h4>To identify the specific intratumoral and microenvironmental heterogeneity of acral melanoma (AM) and mucosal melanoma (MM), we aimed to delineate their distinct cellular compositions, evolutionary trajectories, and subtype-specific therapeutic strategies.<h4>Experimental design</h4>Single-cell transcriptomic and genomic landscapes were analyzed across 42 melanoma (28 AM, 11 MM, and 3 nonacral cutaneous melanoma) samples, supplemented by in vitro and in vivo validation. Tumor and stromal cells were profiled using single-cell RNA sequencing, whole-exome sequencing, and functional assays, including transwell migration, co-culture systems, and xenograft models.<h4>Results</h4>Tumor cells exhibited divergent evolutionary routes, with MM dominated by MGP+/PCOLCE+ subpopulations "],"journal":["Clinical cancer research : an official journal of the American Association for Cancer Research"],"pubmed_title":["Single-Cell Transcriptomic Landscape Deciphers Intratumoral Heterogeneity and Subtypes of Acral and Mucosal Melanomas."],"pmcid":["PMC12163602"],"funding_grant_id":["2021YFA1101000","2021YFA1101004","U21A20379"],"pubmed_authors":["Li C","Jia D","Chen J","Ma X","Wei Z","Zhang R","Yu H","Wang K","Cui R","Qian W","Ren G","Li Y","Zhang Z","Li T","Zhang Y","Cui Z","Chen W","Miao X","Chen Y","Song X","Shi J","Xu Z","Zhou J","Goding CR"],"additional_accession":[]},"is_claimable":false,"name":"Single-Cell Transcriptomic Landscape Deciphers Intratumoral Heterogeneity and Subtypes of Acral and Mucosal Melanomas.","description":"<h4>Purpose</h4>To identify the specific intratumoral and microenvironmental heterogeneity of acral melanoma (AM) and mucosal melanoma (MM), we aimed to delineate their distinct cellular compositions, evolutionary trajectories, and subtype-specific therapeutic strategies.<h4>Experimental design</h4>Single-cell transcriptomic and genomic landscapes were analyzed across 42 melanoma (28 AM, 11 MM, and 3 nonacral cutaneous melanoma) samples, supplemented by in vitro and in vivo validation. Tumor and stromal cells were profiled using single-cell RNA sequencing, whole-exome sequencing, and functional assays, including transwell migration, co-culture systems, and xenograft models.<h4>Results</h4>Tumor cells exhibited divergent evolutionary routes, with MM dominated by MGP+/PCOLCE+ subpopulations ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jun","modification":"2026-06-02T22:28:46.031Z","creation":"2026-04-21T03:13:34.368Z"},"accession":"S-EPMC12163602","cross_references":{"pubmed":["40192737"],"doi":["10.1158/1078-0432.CCR-24-3164"]}}