{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wang M"],"funding":["Noncommunicable Chronic Diseases-National Science and Technology Major Project","Innovative Research Team of High-level Local University in Shanghai","Key Laboratory Program of the Education Commission of Shanghai Municipality","National Natural Science Foundation of China","Shanghai Clinical Research Center of Plastic and Reconstructive Surgery supported by Science and Technology Commission of Shanghai Municipality","Hebei Province Major Science and Technology Support Project"],"pagination":["e2413493"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12165089"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(22)"],"pubmed_abstract":["Adrenal incidentalomas (AIs) are commonly detected endocrine lesions, identified during imaging for unrelated conditions. These lesions exhibit considerable heterogeneity and diverse clinical outcomes. This study employed single-cell RNA sequencing to investigate tumorigenic characteristics of AIs, including non-functional adrenocortical adenomas, Conn's syndrome, and pheochromocytomas. Through integrating public datasets, 302 696 cells are analyzed. Three adrenocortical cell subtypes exhibit gene expression patterns linked to tumorigenesis. Clusterin emerges as a potential biomarker for adrenocortical adenomas. Adrenocortical tumor cells show dysregulated hormone secretion and transcription factor steroidogenic factor 1 (SF1) is significantly upregulated, distinguishing cortical from medu"],"journal":["Advanced science (Weinheim, Baden-Wurttemberg, Germany)"],"pubmed_title":["Single-Cell Atlas Reveals Tumorigenic Profiles and Immune Dynamics of Adrenal Incidentalomas."],"pmcid":["PMC12165089"],"funding_grant_id":["32271165","82070868","82400980","ZDSYS14005","22MC1940300","242W7712Z","82370853","SHSMU-ZDCX20210400","2023ZD0506800"],"pubmed_authors":["Cheng D","Tian F","Liu L","Hu X","Yuan L","Li L","Sun Y","Wang M","Fang X","Li T","Zhang Z","Zhao R","Qi Y","Liu B","Gong K","Zheng G","Chen S","Zhang C","Liu F"],"additional_accession":[]},"is_claimable":false,"name":"Single-Cell Atlas Reveals Tumorigenic Profiles and Immune Dynamics of Adrenal Incidentalomas.","description":"Adrenal incidentalomas (AIs) are commonly detected endocrine lesions, identified during imaging for unrelated conditions. These lesions exhibit considerable heterogeneity and diverse clinical outcomes. This study employed single-cell RNA sequencing to investigate tumorigenic characteristics of AIs, including non-functional adrenocortical adenomas, Conn's syndrome, and pheochromocytomas. Through integrating public datasets, 302 696 cells are analyzed. Three adrenocortical cell subtypes exhibit gene expression patterns linked to tumorigenesis. Clusterin emerges as a potential biomarker for adrenocortical adenomas. Adrenocortical tumor cells show dysregulated hormone secretion and transcription factor steroidogenic factor 1 (SF1) is significantly upregulated, distinguishing cortical from medu","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jun","modification":"2026-06-01T06:25:48.884Z","creation":"2026-04-08T09:51:35.503Z"},"accession":"S-EPMC12165089","cross_references":{"pubmed":["40190189"],"doi":["10.1002/advs.202413493"]}}