{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Singh K"],"funding":["NINDS NIH HHS","NCI NIH HHS","National Institutes of Health","Adaptin Bio"],"pagination":["e181471"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12165802"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["135(12)"],"pubmed_abstract":["The efficacy of T cell-activating therapies against glioma is limited by an immunosuppressive tumor microenvironment and tumor-induced T cell sequestration. We investigated whether peripherally infused nonantigen specific autologous lymphocytes could accumulate in intracranial tumors. We observed that nonspecific autologous CD8+ ALT cells can indeed accumulate in this context, despite endogenous T cell sequestration in bone marrow. Rates of intratumoral accumulation were markedly increased when expanding lymphocytes with IL-7 compared with IL-2. Pretreatment with IL-7 ALT also enhanced the efficacy of multiple tumor-specific and nontumor-specific T cell-dependent immunotherapies against orthotopic murine and human xenograft gliomas. Mechanistically, we detected increased VLA-4 on mouse and"],"journal":["The Journal of clinical investigation"],"pubmed_title":["IL-7-mediated expansion of autologous lymphocytes increases CD8+ VLA-4 expression and accumulation in glioblastoma models."],"pmcid":["PMC12165802"],"funding_grant_id":["R01 CA175517","P50 CA190991","U01 NS090284","393001670","R01 CA235612","P01 CA225622","R01 NS099463","P50-CA190991,P01-CA225622,U01-NS090284,R01-NS099463,R01-CA175517,R01-CA235612"],"pubmed_authors":["Cook SL","Blandford EE","Zhou Y","Noldner P","Moelker EM","Puviindran BJ","Archer GE","Fecci PE","Wallace SE","Khasraw M","Singh K","Shaz BH","Norberg PK","Ayasoufi K","Railton CO","Hotchkiss KM","Sampson JH"],"additional_accession":[]},"is_claimable":false,"name":"IL-7-mediated expansion of autologous lymphocytes increases CD8+ VLA-4 expression and accumulation in glioblastoma models.","description":"The efficacy of T cell-activating therapies against glioma is limited by an immunosuppressive tumor microenvironment and tumor-induced T cell sequestration. We investigated whether peripherally infused nonantigen specific autologous lymphocytes could accumulate in intracranial tumors. We observed that nonspecific autologous CD8+ ALT cells can indeed accumulate in this context, despite endogenous T cell sequestration in bone marrow. Rates of intratumoral accumulation were markedly increased when expanding lymphocytes with IL-7 compared with IL-2. Pretreatment with IL-7 ALT also enhanced the efficacy of multiple tumor-specific and nontumor-specific T cell-dependent immunotherapies against orthotopic murine and human xenograft gliomas. Mechanistically, we detected increased VLA-4 on mouse and","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jun","modification":"2026-06-02T22:28:43.818Z","creation":"2026-04-21T03:13:33.479Z"},"accession":"S-EPMC12165802","cross_references":{"pubmed":["40244705"],"doi":["10.1172/JCI181471"]}}