biostudies-literatureZhou Cthe National Natural Science Foundation of China17562848251346291https://www.ebi.ac.uk/biostudies/studies/S-EPMC12166277biostudies-literatureUnknown18<h4>Background</h4>The relationship between Mediterranean diet (MedDiet) adherence and acute pancreatitis (AP) risk is largely unknown.<h4>Objectives</h4>To investigate the associations between MedDiet adherence and AP risk and joint associations of genetic risk and MedDiet adherence with AP risk.<h4>Design</h4>A prospective cohort study using data from UK Biobank, a large population-based prospective study that recruited over 500,000 participants aged 40-69 between 2006 and 2010 across the United Kingdom.<h4>Methods</h4>We included 103,449 participants free of AP with typical dietary intake from 24-h dietary recalls. MedDiet adherence was measured via the Mediterranean Diet Adherence Screener (MEDAS) continuous score. Genetic predisposition to AP was estimated by polygenic risk score (PRSTherapeutic advances in gastroenterologyMediterranean diet adherence and incident acute pancreatitis: a prospective cohort study.PMC121662778217055982270667Wu ZRuan XChen JZhou CDan LZhang YHuang HGeng JZou DfalseMediterranean diet adherence and incident acute pancreatitis: a prospective cohort study.<h4>Background</h4>The relationship between Mediterranean diet (MedDiet) adherence and acute pancreatitis (AP) risk is largely unknown.<h4>Objectives</h4>To investigate the associations between MedDiet adherence and AP risk and joint associations of genetic risk and MedDiet adherence with AP risk.<h4>Design</h4>A prospective cohort study using data from UK Biobank, a large population-based prospective study that recruited over 500,000 participants aged 40-69 between 2006 and 2010 across the United Kingdom.<h4>Methods</h4>We included 103,449 participants free of AP with typical dietary intake from 24-h dietary recalls. MedDiet adherence was measured via the Mediterranean Diet Adherence Screener (MEDAS) continuous score. Genetic predisposition to AP was estimated by polygenic risk score (PRS2025-01-01T00:00:00Z20252026-06-02T22:29:49.077Z2026-04-21T03:13:45.775ZS-EPMC121662774052045210.1177/17562848251346291