{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["14(7)"],"submitter":["Papa V"],"funding":["SIFI SpA"],"pubmed_abstract":["<h4>Introduction</h4>Acanthamoeba keratitis (AK) was first identified in 1972 and the first patient cured with propamidine was reported in 1985. Treatment outcomes, before the advent of the first effective anti-amoebic treatment, were known to be poor and often required therapeutic keratoplasty (TK) but have not been evaluated in detail. Analysis of these outcomes has value for several reasons: it gives an historical perspective, describes the natural history of AK when the disease was minimally modified by the early treatments and provides a benchmark against which current treatments can be compared and how these have changed the therapeutic results.<h4>Methods</h4>We conducted a systematic literature review for the period 1970-1995 using PRISMA guidelines. The population of interest comp"],"journal":["Ophthalmology and therapy"],"pagination":["1369-1383"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12167199"],"repository":["biostudies-literature"],"pubmed_title":["The Natural History of Acanthamoeba Keratitis: A Systematic Literature Review."],"pmcid":["PMC12167199"],"pubmed_authors":["Bodicoat DH","Duarte AA","Dart JKG","De Francesco M","Papa V"],"additional_accession":[]},"is_claimable":false,"name":"The Natural History of Acanthamoeba Keratitis: A Systematic Literature Review.","description":"<h4>Introduction</h4>Acanthamoeba keratitis (AK) was first identified in 1972 and the first patient cured with propamidine was reported in 1985. Treatment outcomes, before the advent of the first effective anti-amoebic treatment, were known to be poor and often required therapeutic keratoplasty (TK) but have not been evaluated in detail. Analysis of these outcomes has value for several reasons: it gives an historical perspective, describes the natural history of AK when the disease was minimally modified by the early treatments and provides a benchmark against which current treatments can be compared and how these have changed the therapeutic results.<h4>Methods</h4>We conducted a systematic literature review for the period 1970-1995 using PRISMA guidelines. The population of interest comp","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jul","modification":"2026-03-31T11:32:27.336Z","creation":"2025-09-01T03:05:00.269Z"},"accession":"S-EPMC12167199","cross_references":{"pubmed":["40323557"],"doi":["10.1007/s40123-025-01152-9"]}}