biostudies-literatureUnknown16(1)Li XEndometrial cancer (EC) is a malignant tumor originating from the uterine epithelial lining and is one of the most common gynecologic malignancies worldwide. Ubiquitination, as a crucial regulatory mechanism in cell physiology, plays a key role in processes such as cell cycle control, DNA repair, and tumorigenesis. UPF1, a critical regulator of ubiquitination, is involved in the development of various diseases, including cancer, due to its influence on mRNA stability and protein degradation. This study aims to identify novel molecular targets related to EC pathogenesis and to explore their mechanisms of action. Through bioinformatics analysis, we identified ZNF432 as a significantly differentially expressed gene in EC tissues. Functional experiments demonstrated that ZNF432 overexpression Discover oncology1095https://www.ebi.ac.uk/biostudies/studies/S-EPMC12167216biostudies-literatureZNF432 suppresses endometrial cancer progression by promoting UPF1 ubiquitination and inducing apoptosis.PMC12167216Li XQi JZhao SXu RWang SWang CXu SfalseZNF432 suppresses endometrial cancer progression by promoting UPF1 ubiquitination and inducing apoptosis.Endometrial cancer (EC) is a malignant tumor originating from the uterine epithelial lining and is one of the most common gynecologic malignancies worldwide. Ubiquitination, as a crucial regulatory mechanism in cell physiology, plays a key role in processes such as cell cycle control, DNA repair, and tumorigenesis. UPF1, a critical regulator of ubiquitination, is involved in the development of various diseases, including cancer, due to its influence on mRNA stability and protein degradation. This study aims to identify novel molecular targets related to EC pathogenesis and to explore their mechanisms of action. Through bioinformatics analysis, we identified ZNF432 as a significantly differentially expressed gene in EC tissues. Functional experiments demonstrated that ZNF432 overexpression 2025-01-01T00:00:00Z2025 Jun2026-05-29T15:04:43.29Z2025-07-26T03:07:08.226ZS-EPMC121672164051595910.1007/s12672-025-02915-3