{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kaypee S"],"funding":["Japan Society for the Promotion of Science"],"pagination":["283"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12167574"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["23(1)"],"pubmed_abstract":["The nucleolus is the site of rDNA transcription and ribosome biogenesis. Alterations in nucleolar function and architecture correlate with drastic heterochromatin rearrangement and global changes in gene expression. However, the precise mechanism that connects nucleolar function to heterochromatin organization and transcription is yet unknown. Here, we report that the RNA polymerase II (RNA pol II) transactivator and chromatin condenser, Positive Coactivator 4 (PC4), is a bona fide nucleolar protein. PC4 showed dynamic nucleolar accumulation, which is critical for rDNA transcription. The lysine acetyltransferase, KAT5 (Tip60) acetylates PC4 at K35, which facilitates nucleolar release of PC4 and concomitated inhibition of rDNA transcription. By employing PC4 mutant, which is defective in nu"],"journal":["Cell communication and signaling : CCS"],"pubmed_title":["Positive coactivator PC4 shows dynamic nucleolar distribution required for rDNA transcription and protein synthesis."],"pmcid":["PMC12167574"],"funding_grant_id":["20KK0176"],"pubmed_authors":["Igarashi K","Ikura T","Shima H","Kaypee S","Ochiai K","Matsumoto M","Alam M","Kundu TK"],"additional_accession":[]},"is_claimable":false,"name":"Positive coactivator PC4 shows dynamic nucleolar distribution required for rDNA transcription and protein synthesis.","description":"The nucleolus is the site of rDNA transcription and ribosome biogenesis. Alterations in nucleolar function and architecture correlate with drastic heterochromatin rearrangement and global changes in gene expression. However, the precise mechanism that connects nucleolar function to heterochromatin organization and transcription is yet unknown. Here, we report that the RNA polymerase II (RNA pol II) transactivator and chromatin condenser, Positive Coactivator 4 (PC4), is a bona fide nucleolar protein. PC4 showed dynamic nucleolar accumulation, which is critical for rDNA transcription. The lysine acetyltransferase, KAT5 (Tip60) acetylates PC4 at K35, which facilitates nucleolar release of PC4 and concomitated inhibition of rDNA transcription. By employing PC4 mutant, which is defective in nu","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jun","modification":"2026-06-02T22:37:41.163Z","creation":"2026-04-21T03:13:31.57Z"},"accession":"S-EPMC12167574","cross_references":{"pubmed":["40517275"],"doi":["10.1186/s12964-025-02238-4"]}}