biostudies-literatureChen RNational Key Clinical Specialty Construction Projectgoaf040https://www.ebi.ac.uk/biostudies/studies/S-EPMC12167634biostudies-literatureUnknown13Pressurized intraperitoneal aerosol chemotherapy (PIPAC) has emerged as a promising therapeutic approach for treating advanced gastric cancer with peritoneal metastases. Herein, we conducted this meta-analysis to evaluate the feasibility, efficacy, and safety of PIPAC in this patient population. The literature between January 2011 and February 2024 was comprehensively searched on the following databases: PubMed, Embase, Web of Science, and the Cochrane Library. The search, guided by the Population-Intervention-Comparison-Outcome (PICO) framework, focused on studies reporting on the feasibility, efficacy, and safety of PIPAC. Data were pooled by using log transformation (PLN) or Freeman-Tukey double arcsine transformation. Of the 451 initially identified studies, 18 were included in the metGastroenterology reportPressurized intraperitoneal aerosol chemotherapy in advanced gastric cancer with peritoneal metastases: a comprehensive meta-analysis of feasibility, efficacy, and safety.PMC121676342022YW030009Zheng JYang ZLi YYang YLi RChen RWang JfalsePressurized intraperitoneal aerosol chemotherapy in advanced gastric cancer with peritoneal metastases: a comprehensive meta-analysis of feasibility, efficacy, and safety.Pressurized intraperitoneal aerosol chemotherapy (PIPAC) has emerged as a promising therapeutic approach for treating advanced gastric cancer with peritoneal metastases. Herein, we conducted this meta-analysis to evaluate the feasibility, efficacy, and safety of PIPAC in this patient population. The literature between January 2011 and February 2024 was comprehensively searched on the following databases: PubMed, Embase, Web of Science, and the Cochrane Library. The search, guided by the Population-Intervention-Comparison-Outcome (PICO) framework, focused on studies reporting on the feasibility, efficacy, and safety of PIPAC. Data were pooled by using log transformation (PLN) or Freeman-Tukey double arcsine transformation. Of the 451 initially identified studies, 18 were included in the met2025-01-01T00:00:00Z20252026-04-07T20:19:55.606Z2026-04-07T17:36:13.68ZS-EPMC121676344052013110.1093/gastro/goaf040