biostudies-literatureUnknown14(5)Yue X<h4>Background</h4>Colorectal cancer (CRC) is considered one of the main causes of cancer-related deaths. Rho family-interacting cell polarization regulator 1 (<i>RIPOR1</i>) is a new Rho effector protein, and its abnormal expression may be related to various tumors. However, its expression and significance in CRC are still unclear. We aimed to explore its role and potential value in CRC, and to provide a new theoretical basis of prognostic evaluation and targeted therapy for CRC patients.<h4>Methods</h4>Here we investigated the expression and significance of <i>RIPOR1</i> from public databases by using bioinformatics methods. Immunohistochemistry (IHC) was performed to determine protein expression levels of <i>RIPOR1</i> in CRC patients, and the correlation between <i>RIPOR1</i> expressioTranslational cancer research2707-2721https://www.ebi.ac.uk/biostudies/studies/S-EPMC12170205biostudies-literatureIncreased expression of <i>RIPOR1</i> predicts the poor prognosis of colorectal cancer patients.PMC12170205Dong ZChen YBian JYue XfalseIncreased expression of <i>RIPOR1</i> predicts the poor prognosis of colorectal cancer patients.<h4>Background</h4>Colorectal cancer (CRC) is considered one of the main causes of cancer-related deaths. Rho family-interacting cell polarization regulator 1 (<i>RIPOR1</i>) is a new Rho effector protein, and its abnormal expression may be related to various tumors. However, its expression and significance in CRC are still unclear. We aimed to explore its role and potential value in CRC, and to provide a new theoretical basis of prognostic evaluation and targeted therapy for CRC patients.<h4>Methods</h4>Here we investigated the expression and significance of <i>RIPOR1</i> from public databases by using bioinformatics methods. Immunohistochemistry (IHC) was performed to determine protein expression levels of <i>RIPOR1</i> in CRC patients, and the correlation between <i>RIPOR1</i> expressio2025-01-01T00:00:00Z2025 May2026-06-03T03:05:30.516Z2026-04-23T03:13:34.987ZS-EPMC121702054053016010.21037/tcr-24-2029