{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8(1)"],"submitter":["Taylor KI"],"pubmed_abstract":["Digital health technology (DHT) tools for Parkinson's disease (PD) e.g., smartphones and wearables were used for remote and frequent measurement of motor signs in the phase 2 PASADENA study of the anti-alpha-synuclein monoclonal antibody prasinezumab. 316 early-stage PD participants were randomized to placebo, 1500 mg, or 4500 mg prasinezumab for 52 weeks; placebo participants were re-randomized to prasinezumab for the ensuing 52 weeks. Patients performed daily smartphone motor \"active tests\", and were passively monitored by smartphone/smartwatch throughout the day over 2 y. Change from baseline analyses censored data at dopaminergic treatment start. Bilateral speeded tapping variability and hand-turning, U-turn speed, passively monitored hand movement power, and summary Simple Sum scores "],"journal":["NPJ digital medicine"],"pagination":["365"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12170883"],"repository":["biostudies-literature"],"pubmed_title":["Exploratory digital outcome measures of motor sign progression in Parkinson's disease patients treated with prasinezumab."],"pmcid":["PMC12170883"],"pubmed_authors":["Remy P","Popp W","Abt M","Fang J","Borngraber F","Goodman I","Bamdadian A","Ansquer S","Luthra N","Gasser T","Zimmermann M","Benatru I","Prasinezumab Study Group","Patel P","Patel N","Wright B","Bichon A","Ellenbogen A","Spampinato U","Bette S","Taylor C","Hoglinger G","Pahwa R","Holiga S","Manchester M","Poirier A","Samaniego D","Gibbons J","Katz M","Durif F","Frank S","Vazquez IE","David E","Hahn A","Russell D","Fluchere F","Honer M","Hui J","Sergo V","Shill H","Passemard B","Klos K","Rumpf JJ","Del Pozo SL","Marchesi M","Post A","Lambrecht S","Corvol JC","Zuzuarregui R","Klos S","Pagano G","Dietiker C","Levy O","Morrison P","Umbricht D","Calvas F","Lopez R","Zanigni S","Debilly B","Summers D","Niggli M","Shariati N","Fontoura P","Moro E","Delfini MH","Pross N","Deptula D","Peckham E","Essioux L","Manzanares LL","Pape H","Benchetrit E","Graziella M","Schnitzler A","Aslam S","Taylor KI","Barata T","Schwartzbard J","Rukina D","Quinn J","Doody R","Volkova-Volkmar E","Cosgaya M","Giordana C","Seppi K","Janzen A","Schjodt-Eriksen J","Martin-Facklam M","Davis T","Muehlberg C","Strasak A","Jiao J","Meoni S","Derost P","Goubeaud M","Luzy C","Mariani LL","Boess F","Marco HB","Boyd J","de Toledo M","Gailitzky M","Verselis L","Corbille AG","Tarakad A","Vergnet S","Kremer T","Isaacson S","Hernandez A","Puido MRL","Eickoff C","Madueno SE","Hernandez-Vara J","Fries F","Feigenbaum D","Besharat A","Multani M","Britschgi M","Roeben B","Ewert S","Kuhn A","Siderowf A","Machetanz G","Schorr O","Mollenhauer B","Ebentheuer J","Anandan C","Martinez AG","PASADENA Investigators","Maltete D","Moon J","Cosson V","Sarry C","Billnitzer A","Martinez S","Toothaker T","Castrioto A","Fradet A","Marques A","Carbone F","Ellmerer P","Bernhard F","Morena JMG","Marti G","Czech C","Gasca C","Macias Y","Palasis A","Dotor J","Perez J","Cheriet S","Walsh R","Perez R","Weber C","Hartmann A","Huebl J","Hartmann C","Marini K","Petit A","Martenyi F","Catala H","Levin J","Lipsmeier F","Eusebio A","Arrouasse R","Weber S","Thalamus C","Bojarsky JK","Dean M","Hassell T","Laurens B","Moore E","Brodsky M","Kobet C","Wegschneider M","Waters C","Foubert-Samier A","Barbet N","Tanner C","Bardram K","Scelsi MA","Classen J","Dziadek S","Maass S","Martinez DM","Coleman R","Richard I","Damier P","Edgar C","Dukart J","Kadimi S","Guimaraes-Costa R","Altendorf C","Sriram A","Fraix V","Dahodwala N","Kunz M","Vidal T","Witjas T","Ostrowitzki S","Deuel L","Martinez EB","Chan J","Nicholas A","Svoboda H","Hauser R","Wurster I","Vogt A","Coleman J","Murphy C","Deik A","Lyons K","Vela L","Fernandez LC","Van Blercom N","Compta Y","Peball M","Kilchenmann T","Bonni A","Davies E","Diack C","Bega D","Preterre C","Jankovic J","Dimenshteyn K","Casse-Parrot C","Fournier M","Postuma RB","Andrews G","Horta A","Hernandez AMD","Eggert KM","Miro JUM","Borroni E","Rascol O","Staunton H","Barbu S","Marin J","Lindemann M","Vanegas-Arrogave N","Schweyer K","Baker J","Houeto JL","Ricci B","Jadidi S","Voglein J","Weidinger E","Belli S","Kassubek RJ","Sink K","Canelo M","Poewe W","D'Urso G","Prasad M","Perez MG","Brown E","Carroll C","Kumar R","Kurvits L","Monnet A","Litvan I","Longardner K","Kustermann T","Kaminski P","Schubert C","Finch R","Sevigny J","Boraud T","Lizarraga K","Stover N","Gorospe A","Grimaldi S","Boulay A","Meissner W","DeGiorgio J","Peery T","Azula JP","Samier-Foubert A","Wenzel G","Anzures-Cabrera J","Nikolcheva T","Bruecke C","Joseph X","Trundell D","Blondeau S","Weill C","Gruenbauer W","Laganiere S","Koebert J","Sanchez-Ferro A","Brockmann K","Krause P","Pinkhardt E","Landsdall C","Simuni T","Grabli D","Mironova K","Cristobal GL","Reuther E","Domenech MJM","Farell M","Homedes C","Kannenberg S","Pomies E","Ciabarra A","Witt PL","Salhi H","Rose E","Delaby L","Kwei K","Schmitt E","Derkinderen P","Gross J","Zago W"],"additional_accession":[]},"is_claimable":false,"name":"Exploratory digital outcome measures of motor sign progression in Parkinson's disease patients treated with prasinezumab.","description":"Digital health technology (DHT) tools for Parkinson's disease (PD) e.g., smartphones and wearables were used for remote and frequent measurement of motor signs in the phase 2 PASADENA study of the anti-alpha-synuclein monoclonal antibody prasinezumab. 316 early-stage PD participants were randomized to placebo, 1500 mg, or 4500 mg prasinezumab for 52 weeks; placebo participants were re-randomized to prasinezumab for the ensuing 52 weeks. Patients performed daily smartphone motor \"active tests\", and were passively monitored by smartphone/smartwatch throughout the day over 2 y. Change from baseline analyses censored data at dopaminergic treatment start. Bilateral speeded tapping variability and hand-turning, U-turn speed, passively monitored hand movement power, and summary Simple Sum scores ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jun","modification":"2026-06-01T12:01:37.737Z","creation":"2026-05-18T03:07:40.19Z"},"accession":"S-EPMC12170883","cross_references":{"pubmed":["40523921"],"doi":["10.1038/s41746-025-01572-8"]}}