biostudies-literatureMorse LRCraig H. Neilsen Foundatione1301https://www.ebi.ac.uk/biostudies/studies/S-EPMC12173286biostudies-literatureUnknown10(4)<h4>Objective</h4>Assess feasibility, safety, and tolerability of 3 months of oral brivaracetam for severe (9-10/10) spinal cord injury-related neuropathic pain.<h4>Methods</h4>We conducted a multisite pilot study where adults were randomized to 3 months of brivaracetam (100 mg BID) or placebo. Pain was assessed via the Brief Pain Inventory, the International Spinal Cord Injury Pain Basic Dataset (version 2.0), and a daily pain diary.<h4>Results</h4>We enrolled 24 participants across 2 sites and 14 participants were included in the final analysis (n = 8 placebo, n = 6 brivaracetam). The drug was tolerated with expected, nonserious side effects (nausea if taken on an empty stomach, fatigue that improved after 2-3 days). Side effects were more common in the brivaracetam group (73%, n = 8 vs Pain reportsBrivaracetam for spinal cord injury-related neuropathic pain: results of a pilot double-blinded, randomized, placebo-controlled clinical trial.PMC12173286652052Anderton GGoldstein RWudlick RDeVries BNguyen NStillman MBattaglino RAFalci SPWelch ALinnman CGlossner JMorse LRBattaglino ALfalseBrivaracetam for spinal cord injury-related neuropathic pain: results of a pilot double-blinded, randomized, placebo-controlled clinical trial.<h4>Objective</h4>Assess feasibility, safety, and tolerability of 3 months of oral brivaracetam for severe (9-10/10) spinal cord injury-related neuropathic pain.<h4>Methods</h4>We conducted a multisite pilot study where adults were randomized to 3 months of brivaracetam (100 mg BID) or placebo. Pain was assessed via the Brief Pain Inventory, the International Spinal Cord Injury Pain Basic Dataset (version 2.0), and a daily pain diary.<h4>Results</h4>We enrolled 24 participants across 2 sites and 14 participants were included in the final analysis (n = 8 placebo, n = 6 brivaracetam). The drug was tolerated with expected, nonserious side effects (nausea if taken on an empty stomach, fatigue that improved after 2-3 days). Side effects were more common in the brivaracetam group (73%, n = 8 vs 2025-01-01T00:00:00Z2025 Aug2026-06-02T22:29:50.219Z2026-04-21T03:13:46.043ZS-EPMC121732864052884310.1097/PR9.0000000000001301