biostudies-literatureUnknown97(6)de Oliveira KGThis study was supported by PROADI_SUS.Hepatitis A Virus (HAV) infects millions of individuals annually and is a major cause of acute viral hepatitis worldwide. This study aims to (1) assess HAV infection in suspected acute hepatitis patients at public healthcare institutions in Brazil; (2) evaluate the proportion of immunized individuals against HAV; (3) identify HAV genotypes; (4) examine the association between HAV infection and demographic data, as well as exposure to risk factors. This is a prospective, observational multicenter study conducted in primary health services in Brazil from October 2019 to May 2023, involving 1721 patients with suspected acute hepatitis. Acute HAV infection was identified in 108 (6.3%) patients, predominantly in young men (80%) and from South and Southeast regions of Brazil (97%). Anti-HAV IgG,Journal of medical virologye70449https://www.ebi.ac.uk/biostudies/studies/S-EPMC12175488biostudies-literatureA Comprehensive Molecular and Serological Investigation of Hepatitis A Virus Among Patients With Suspected Acute Hepatitis: A Brazilian Study.PMC12175488de Oliveira GSSGonzalez MPTenore SParana RNastri ACSSCoral GPGurski APMVasconcelos MPACasadio LVBSiqueira RALopes EPAFanis BEACastberg LSchinoni MICarrilho FJLucena MGuedes MDCAlvares-da-Silva MRPinto ASMaluf MMEmerim EOrnelas Pereira Salvador de Oliveira Dde Mello Malta FAcosta PRFerreira PRADomingues TSPMendes-Correa MCJUehara SNOXimenez LLInoue CAGdalevici CAmgarten DVillar LMDorlass ESalomao APimenta MCGarcia RFLNascimento-Sales Mde Almeida ECde Souza FMABertolini DAde Azevedo RSLuiz MCMunoz Torres PAGomes-Gouvea MSSouza FFPereira GFMHyppolito EFerreira ASitnik RSelegatto Gde Oliveira KGPinho JRRPanico CTSouto FFerraz MLGArrojo RSTon JTRobinson PJLeite OHMTeixeira RLobato CMDOSebe PReuter TfalseA Comprehensive Molecular and Serological Investigation of Hepatitis A Virus Among Patients With Suspected Acute Hepatitis: A Brazilian Study.Hepatitis A Virus (HAV) infects millions of individuals annually and is a major cause of acute viral hepatitis worldwide. This study aims to (1) assess HAV infection in suspected acute hepatitis patients at public healthcare institutions in Brazil; (2) evaluate the proportion of immunized individuals against HAV; (3) identify HAV genotypes; (4) examine the association between HAV infection and demographic data, as well as exposure to risk factors. This is a prospective, observational multicenter study conducted in primary health services in Brazil from October 2019 to May 2023, involving 1721 patients with suspected acute hepatitis. Acute HAV infection was identified in 108 (6.3%) patients, predominantly in young men (80%) and from South and Southeast regions of Brazil (97%). Anti-HAV IgG,2025-01-01T00:00:00Z2025 Jun2026-06-02T00:31:14.84Z2026-05-24T03:07:13.432ZS-EPMC121754884053067010.1002/jmv.70449