{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["He X"],"funding":["Orthopaedic Medical Innovation Center of Jiangsu","Key Laboratory of Orthopaedics of Suzhou","National Natural Science Foundation of China","Technology Innovation on Medicine and Health of Suzhou Science and Technology Bureau"],"pagination":["457"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12180219"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["23(1)"],"pubmed_abstract":["Inflammatory infiltration and inappropriate friction remain the two main challenges in treating osteoarthritis (OA). An effective treatment platform is anticipated to lubricate the cartilage and ameliorate intra-articular inflammation. Herein, injectable hydrogel microspheres with chondroitin sulfate (Chs)/sericin methacryloyl (SerMA) designed as the core and grafted with folic acid (FA)- and 78c-modified liposomes (78c@Lipo-FA) by DSPE-PEG2k-GPLGLAGQC (DPG) peptides, namely LFDCS, was formed by thin-film hydration and microfluidic methods. Physically, LFDCS exhibited cartilage lubrication and adhesion capability as the bionic bearings. Meanwhile, with the degradation of LFDCS, Chs were set out to promote chondrocyte function. Physiologically, 78c@Lipo-FA were released from LFDCS enzymatic"],"journal":["Journal of nanobiotechnology"],"pubmed_title":["Bionic bearing-inspired lubricating microspheres with Immunomodulatory effects for osteoarthritis therapy."],"pmcid":["PMC12180219"],"funding_grant_id":["CXZX202209","SZS2022017","82172485, 82372457, 82472426","SKY2022041, SKY2023147, SSD2024028"],"pubmed_authors":["Liu X","Yang H","He X","Shi Q","Niu J","Chen Y","Wang Y","Zhou Y","Cheng X","Shen H","Zhu C","Xu Y"],"additional_accession":[]},"is_claimable":false,"name":"Bionic bearing-inspired lubricating microspheres with Immunomodulatory effects for osteoarthritis therapy.","description":"Inflammatory infiltration and inappropriate friction remain the two main challenges in treating osteoarthritis (OA). An effective treatment platform is anticipated to lubricate the cartilage and ameliorate intra-articular inflammation. Herein, injectable hydrogel microspheres with chondroitin sulfate (Chs)/sericin methacryloyl (SerMA) designed as the core and grafted with folic acid (FA)- and 78c-modified liposomes (78c@Lipo-FA) by DSPE-PEG2k-GPLGLAGQC (DPG) peptides, namely LFDCS, was formed by thin-film hydration and microfluidic methods. Physically, LFDCS exhibited cartilage lubrication and adhesion capability as the bionic bearings. Meanwhile, with the degradation of LFDCS, Chs were set out to promote chondrocyte function. Physiologically, 78c@Lipo-FA were released from LFDCS enzymatic","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jun","modification":"2025-07-25T03:08:16.027Z","creation":"2025-07-25T03:08:16.027Z"},"accession":"S-EPMC12180219","cross_references":{"pubmed":["40542398"],"doi":["10.1186/s12951-025-03544-2"]}}