{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Haun H"],"funding":["National Institute on Alcohol Abuse and Alcoholism","NIAAA NIH HHS","National Institutes of Health"],"pagination":["115482"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12181985"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["44(4)"],"pubmed_abstract":["High-intensity alcohol drinking during binge episodes contributes to the socioeconomic burden created by alcohol use disorders (AUDs), and nociceptin receptor (NOP) antagonists have emerged as a promising intervention. To better understand the contribution of the NOP system to binge drinking, we found that nociceptin-containing neurons of the lateral septum (LS<sup>Pnoc</sup>) displayed increased excitability during withdrawal from binge-like alcohol drinking. LS<sup>Pnoc</sup> activation promoted active avoidance and potentiated binge-like drinking behavior, whereas silencing of this population reduced alcohol drinking. LS<sup>Pnoc</sup> form robust monosynaptic inputs locally within the LS and genetic deletion of NOP or microinjection of a NOP antagonist into the LS decreased alcohol int"],"journal":["Cell reports"],"pubmed_title":["Septo-hypothalamic regulation of binge-like alcohol consumption by the nociceptin system."],"pmcid":["PMC12181985"],"funding_grant_id":["F32AA030494","F32AA031395","R01 AA019454","F32 AA031395","F32 AA030494","P60 AA011605","K99 AA030628","P60AA011605","U01AA020911","U01 AA020911","T32AA007573","T32 AA007573"],"pubmed_authors":["Haun H","Roland A","Yan L","Lee S","Flanigan M","Kash T","Hernandez R","Hon O","Taxier L","Mendez H"],"additional_accession":[]},"is_claimable":false,"name":"Septo-hypothalamic regulation of binge-like alcohol consumption by the nociceptin system.","description":"High-intensity alcohol drinking during binge episodes contributes to the socioeconomic burden created by alcohol use disorders (AUDs), and nociceptin receptor (NOP) antagonists have emerged as a promising intervention. To better understand the contribution of the NOP system to binge drinking, we found that nociceptin-containing neurons of the lateral septum (LS<sup>Pnoc</sup>) displayed increased excitability during withdrawal from binge-like alcohol drinking. LS<sup>Pnoc</sup> activation promoted active avoidance and potentiated binge-like drinking behavior, whereas silencing of this population reduced alcohol drinking. LS<sup>Pnoc</sup> form robust monosynaptic inputs locally within the LS and genetic deletion of NOP or microinjection of a NOP antagonist into the LS decreased alcohol int","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Apr","modification":"2026-05-29T14:29:10.186Z","creation":"2026-04-08T05:04:12.434Z"},"accession":"S-EPMC12181985","cross_references":{"pubmed":["40153436"],"doi":["10.1016/j.celrep.2025.115482"]}}