biostudies-literatureBommhardt TGemeinsame Bundesausschusse103151https://www.ebi.ac.uk/biostudies/studies/S-EPMC12182174biostudies-literatureUnknown15(6)<h4>Introduction</h4>Psychosis, characterised by chronic symptoms often emerging in youth, imposes a substantial burden on individuals and healthcare systems. While early detection and intervention can mitigate this burden, there is limited evidence on the cost-effectiveness of such approaches. To address this lack of evidence, this study protocol outlines the health economic implications of an artificial intelligence (AI)-based intervention, the Computer-Assisted Risk-Evaluation (CARE), designed to prevent psychosis. The intervention uses AI technologies to enhance the diagnosis and treatment quality for individuals at high risk of psychosis.<h4>Methods and analysis</h4>The health economic evaluation has been designed alongside a 12-month multicentre randomised controlled trial comparing BMJ openEnhancing early detection and treatment of psychosis in Germany: a protocol for the health economic evaluation of an artificial intelligence-guided complex intervention.PMC1218217401NVF20004Wiegel MRitters AHoppe MDaub JStrasser AMHuber TZimmermann JBrauckmann SWiesner FKnopp KSchulz LMier DSchlagenhauf FLieberz DRau AKambeitz-Ilankovic LGrotegerd DBonnekoh LMBecher LRomer GHohmann SSolz JVTZEberle CMroß MSmid AKlos BHirjak DKujovic MWasserscheid AWeyer CSchultze-Lutter FWasserthal SSchafer EBender SSchnellbacher GTheisen CRomanos MMeyhofer IHackler SGreiner SKKatthagen TCARE Study GroupNieberler MHasan ANeuner LMSchwarz ENaujoks CHeide MZiegler GDrusenheimer NBechdolf AHutz BEickhoff SHolzner LCorrell CBotterweck SFlechtner HHRieß CKruger LMalkewitz CInanloo-Shavikloo SSchmidt SJGerth CHage AQuant EPoll RMuller SDohrn OHippe AHeuer FHArlt NRBoettcher JSander CGhanam ARMeisenzahl ESenner SGeissler JStumpp SJessen FLingen AVPfennig ARiedlinger SWrulich MKilian BReissner VHuss MMuller EBerndt CAssadi ZFeil NTlach LMaicher BMunz MDiedrich PSteinwand PHeinz AGotze SKesik JMeyer-Lindenberg ASowada PUhlhaas PJRosen MReiring PLipp MSeefeldt LWolf VLeopold KRohenkohl ACOsman NWirsching PJBaumgartner AKoln PIncesoy EIEuent MSammoum FBoehm IKranenburg BGenccagj DCoppicus LSievert KStrehlow AGoder RKanlidere SPalm PBauer MSchomerus GNeuner ISauer JVega DAGQuinlivan EHardenberg LVRehe CShishechian SKlupfel CLenders CGramsch CBommhardt TSynetou AKramer RFrings MHeindl PKallmeyer MHoffmann KSteiner JKoutsouleris NShmuilovich OGesell DUnsold SConrad AKittel-Schneider SHaupt MFranzen LJaschinski-Weber TRieck JHStrube WKim JBrockel-Bundt KGorlitz TJedamzik TWege NKopke CKrcmar LCabrera SBijlard NCalles CGliemann MWunram HLStohr ABothig ABanaschewski TZoll MAster HCGallinat JSchneider MFink DBirner RSDaly VELeyens UPhilipsen ADannlowski UJung LSchwinde HLoy JLambert MHerwig USchumacher NBley LHuppertz MRohner HThiemann UCoelen CVBarth GMKlingberg SRenner TGellert SGabriel JMedenbach JKaminski JRiedel AEleftheriadis MDeiß MGoltermann JMichel JFausel JWenzel JVera Lennartz PMSchroll MMey MMeister KHuth FBecker KWolber ABalzar AWalther SPeschl JGladbach MSpahlholz JJohannsen MKambeitz JKoberlein-Neu JMollamehmetoglu DPalacio SFFallgatter AJGersie MGrand ADaniels JWahl MRuef ABorgwardt SSoyka ONikolic MMennigen EWeigand SPlett CAndreou CSeidenbecher SNeumann SNiemann NSJuckel GVolkmer SBorovik EMandl SBori-Kovacs EWoopen CFrodl TMatti NSchulte-Korne GRau AKGaus RfalseEnhancing early detection and treatment of psychosis in Germany: a protocol for the health economic evaluation of an artificial intelligence-guided complex intervention.<h4>Introduction</h4>Psychosis, characterised by chronic symptoms often emerging in youth, imposes a substantial burden on individuals and healthcare systems. While early detection and intervention can mitigate this burden, there is limited evidence on the cost-effectiveness of such approaches. To address this lack of evidence, this study protocol outlines the health economic implications of an artificial intelligence (AI)-based intervention, the Computer-Assisted Risk-Evaluation (CARE), designed to prevent psychosis. The intervention uses AI technologies to enhance the diagnosis and treatment quality for individuals at high risk of psychosis.<h4>Methods and analysis</h4>The health economic evaluation has been designed alongside a 12-month multicentre randomised controlled trial comparing 2025-01-01T00:00:00Z2025 Jun2026-06-02T22:39:37.063Z2026-04-21T03:14:11.012ZS-EPMC121821744053322210.1136/bmjopen-2025-103151