{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Chan H"],"funding":["NIDDK NIH HHS","NIAID NIH HHS","NIAMS NIH HHS"],"pagination":["eads0519"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12183641"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10(106)"],"pubmed_abstract":["Infections after psychological stress are a major health care problem. Single-cell transcriptomics and lipidomic profiling in a mouse model of stress show that dermal fibroblasts undergoing adipogenesis have defective responses to <i>Staphylococcus aureus</i> skin infection. Adrenalectomy or adrenergic inhibition restores the fibroblast adipogenic response to <i>S. aureus</i> and enables mice to effectively resist infection during stress. Increased susceptibility to <i>S. aureus</i> from stress is attributed to suppression of the antimicrobial peptide cathelicidin (<i>Camp</i>) because adrenaline directly inhibits <i>Camp</i> production by fibroblasts, and mice lacking <i>Camp</i> in fibroblasts do not increase infection after stress. Transforming growth factor β (TGFβ) is induced by stres"],"journal":["Science immunology"],"pubmed_title":["Psychological stress increases skin infection through the action of TGFβ to suppress immune-acting fibroblasts."],"pmcid":["PMC12183641"],"funding_grant_id":["P50 AR080594","R01 DK128787","U01 AI152038","R37 AI052453","R01 AI168005"],"pubmed_authors":["Chan H","Nakatsuji T","Li H","Dokoshi T","Crown B","Chiu IM","Gallo RL","Li F","Cavagnero KJ","Li Q","Yang D","Williams KJ","Aguilera C","Bensinger SJ","Chen W","Valentina O","Chen Y","Liu E","Indra A","Numata T"],"additional_accession":[]},"is_claimable":false,"name":"Psychological stress increases skin infection through the action of TGFβ to suppress immune-acting fibroblasts.","description":"Infections after psychological stress are a major health care problem. Single-cell transcriptomics and lipidomic profiling in a mouse model of stress show that dermal fibroblasts undergoing adipogenesis have defective responses to <i>Staphylococcus aureus</i> skin infection. Adrenalectomy or adrenergic inhibition restores the fibroblast adipogenic response to <i>S. aureus</i> and enables mice to effectively resist infection during stress. Increased susceptibility to <i>S. aureus</i> from stress is attributed to suppression of the antimicrobial peptide cathelicidin (<i>Camp</i>) because adrenaline directly inhibits <i>Camp</i> production by fibroblasts, and mice lacking <i>Camp</i> in fibroblasts do not increase infection after stress. Transforming growth factor β (TGFβ) is induced by stres","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Apr","modification":"2026-06-03T07:10:44.236Z","creation":"2026-04-25T03:22:41.312Z"},"accession":"S-EPMC12183641","cross_references":{"pubmed":["40215323"],"doi":["10.1126/sciimmunol.ads0519"]}}