biostudies-literatureSmith SLVersus ArthritisNational Institute for Health Research (NIHR)Wellcome Truste1295https://www.ebi.ac.uk/biostudies/studies/S-EPMC12185087biostudies-literatureUnknown10(4)<h4>Introduction</h4>The central nervous system (CNS) contributes to pain perception across musculoskeletal conditions. The central aspects of pain (CAP) questionnaire captures a single score associated with quantitative sensory testing (QST) evidence of CNS dysfunction validated in knee osteoarthritis.<h4>Objectives</h4>Given the different pathophysiology of rheumatoid arthritis (RA), an inflammatory polyarthritis, this cross-sectional study assessed CAP's psychometric properties and its association with pain in RA.<h4>Methods</h4>Adults with RA were recruited from Nottinghamshire, London, and Cardiff. Participants completed CAP and reported pain using a numerical rating scale. A subgroup underwent additional assessments, including quantitative sensory testing (QST; Pressure Pain detectioPain reportsValidity and contributions to pain from the central aspects of pain questionnaire in rheumatoid arthritis.PMC12185087224257/Z/21/Z2246220777NIHR301674Ledbury SMcWilliams DFPlatts DIfesemen OSPickles TRutter-Locher ZKirkham BJames RWilson DWalsh DAGeorgopoulos VChoy EFerguson EWakefield RJBuckley PSmith SLfalseValidity and contributions to pain from the central aspects of pain questionnaire in rheumatoid arthritis.<h4>Introduction</h4>The central nervous system (CNS) contributes to pain perception across musculoskeletal conditions. The central aspects of pain (CAP) questionnaire captures a single score associated with quantitative sensory testing (QST) evidence of CNS dysfunction validated in knee osteoarthritis.<h4>Objectives</h4>Given the different pathophysiology of rheumatoid arthritis (RA), an inflammatory polyarthritis, this cross-sectional study assessed CAP's psychometric properties and its association with pain in RA.<h4>Methods</h4>Adults with RA were recruited from Nottinghamshire, London, and Cardiff. Participants completed CAP and reported pain using a numerical rating scale. A subgroup underwent additional assessments, including quantitative sensory testing (QST; Pressure Pain detectio2025-01-01T00:00:00Z2025 Aug2026-06-03T06:56:46.674Z2026-04-25T03:22:11.02ZS-EPMC121850874055174610.1097/PR9.0000000000001295